Development of diabetic ketoacidosis in an AIDS patient being treated with megestrol acetate for cachexia

Gina E. White, Allan E Rodriguez, Malmood Almed Butt, Virgil R. Lijfrock

Research output: Contribution to journalArticle

Abstract

Objective: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS. Case Summary: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia. Discussion: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy. Conclusions: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.

Original languageEnglish
Pages (from-to)106-109
Number of pages4
JournalJournal of Pharmacy Technology
Volume14
Issue number3
StatePublished - May 1 1998

Fingerprint

Megestrol Acetate
Diabetic Ketoacidosis
Cachexia
Acquired Immunodeficiency Syndrome
Hyperglycemia
Muscle Rigidity
Mobility Limitation
Glucose Intolerance
Anorexia
Therapeutics
Signs and Symptoms
Suspensions
Tuberculosis

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Development of diabetic ketoacidosis in an AIDS patient being treated with megestrol acetate for cachexia. / White, Gina E.; Rodriguez, Allan E; Butt, Malmood Almed; Lijfrock, Virgil R.

In: Journal of Pharmacy Technology, Vol. 14, No. 3, 01.05.1998, p. 106-109.

Research output: Contribution to journalArticle

White, Gina E. ; Rodriguez, Allan E ; Butt, Malmood Almed ; Lijfrock, Virgil R. / Development of diabetic ketoacidosis in an AIDS patient being treated with megestrol acetate for cachexia. In: Journal of Pharmacy Technology. 1998 ; Vol. 14, No. 3. pp. 106-109.
@article{77a6199c5a134e05b67b54a5d0b4fbf4,
title = "Development of diabetic ketoacidosis in an AIDS patient being treated with megestrol acetate for cachexia",
abstract = "Objective: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS. Case Summary: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia. Discussion: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy. Conclusions: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.",
author = "White, {Gina E.} and Rodriguez, {Allan E} and Butt, {Malmood Almed} and Lijfrock, {Virgil R.}",
year = "1998",
month = "5",
day = "1",
language = "English",
volume = "14",
pages = "106--109",
journal = "Journal of Pharmacy Technology",
issn = "8755-1225",
publisher = "Harvey Whitney Books Company",
number = "3",

}

TY - JOUR

T1 - Development of diabetic ketoacidosis in an AIDS patient being treated with megestrol acetate for cachexia

AU - White, Gina E.

AU - Rodriguez, Allan E

AU - Butt, Malmood Almed

AU - Lijfrock, Virgil R.

PY - 1998/5/1

Y1 - 1998/5/1

N2 - Objective: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS. Case Summary: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia. Discussion: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy. Conclusions: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.

AB - Objective: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS. Case Summary: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia. Discussion: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy. Conclusions: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.

UR - http://www.scopus.com/inward/record.url?scp=0031806917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031806917&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 106

EP - 109

JO - Journal of Pharmacy Technology

JF - Journal of Pharmacy Technology

SN - 8755-1225

IS - 3

ER -