TY - JOUR
T1 - Development of diabetic ketoacidosis in an AIDS patient being treated with megestrol acetate for cachexia
AU - White, Gina E.
AU - Rodriguez, Allan
AU - Butt, Malmood Almed
AU - Lijfrock, Virgil R.
PY - 1998/5/1
Y1 - 1998/5/1
N2 - Objective: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS. Case Summary: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia. Discussion: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy. Conclusions: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.
AB - Objective: To report a case of diabetic ketoacidosis induced by megestrol acetate in a patient with AIDS. Case Summary: A 46-year-old Haitian man arrived at our tuberculosis clinic with a 1-week history of difficulty walking, confusion, nuchal rigidity, and incontinence. On admission to the hospital, diabetic ketoacidosis was diagnosed, and appropriate treatment was started. The patient did not have a history of hyperglycemia, diabetes, or antiretroviral therapy that may have predisposed him to glucose intolerance. However, 6 weeks before admission, he was prescribed megestrol acetate suspension for anorexia. Discussion: Several cases of hyperglycemia induced by megestrol acetate in AIDS patients have been reported. However, to our knowledge, this is the first report of a patient presenting with diabetic ketoacidosis secondary to megestrol acetate therapy. Conclusions: In AIDS patients with cachexia who exhibit signs and symptoms of hyperglycemia without an obvious cause, megestrol acetate therapy may need to be discontinued.
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M3 - Article
AN - SCOPUS:0031806917
VL - 14
SP - 106
EP - 109
JO - Journal of Pharmacy Technology
JF - Journal of Pharmacy Technology
SN - 8755-1225
IS - 3
ER -