Development of anxiety: The role of threat appraisal and fear learning

Jennifer C Britton, Shmuel Lissek, Christian Grillon, Maxine A. Norcross, Daniel S. Pine

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Anxious individuals exhibit threat biases at multiple levels of information processing. From a developmental perspective, abnormal safety learning in childhood may establish threat-related appraisal biases early, which may contribute to chronic disorders in adulthood. This review illustrates how the interface among attention, threat appraisal, and fear learning can generate novel insights for outcome prediction. This review summarizes data on amygdala function, as it relates to learning and attention, highlights the importance of examining threat appraisal, and introduces a novel imaging paradigm to investigate the neural correlates of threat appraisal and threat-sensitivity during extinction recall. This novel paradigm can be used to investigate key questions relevant to prognosis and treatment. Depression and Anxiety, 2011.

Original languageEnglish
Pages (from-to)5-17
Number of pages13
JournalDepression and Anxiety
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Fear
Anxiety
Learning
Amygdala
Automatic Data Processing
Depression
Safety
Therapeutics
Psychological Extinction

Keywords

  • amygdala
  • attention
  • fear conditioning
  • generalization
  • ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Development of anxiety : The role of threat appraisal and fear learning. / Britton, Jennifer C; Lissek, Shmuel; Grillon, Christian; Norcross, Maxine A.; Pine, Daniel S.

In: Depression and Anxiety, Vol. 28, No. 1, 01.01.2011, p. 5-17.

Research output: Contribution to journalArticle

Britton, Jennifer C ; Lissek, Shmuel ; Grillon, Christian ; Norcross, Maxine A. ; Pine, Daniel S. / Development of anxiety : The role of threat appraisal and fear learning. In: Depression and Anxiety. 2011 ; Vol. 28, No. 1. pp. 5-17.
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