Development of antimicrobials for wound care: In-vitro and in-vivo assessments

Stephen C. Davis, Navid Bouzari

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

In the development of antimicrobial agents, the use of both in-vitro and in-vivo models is essential for successful outcomes. In-vitro tests are necessary to help determine initial dose-response data as well as to evaluate potential susceptibility and/or resistance of specific pathogens. The employment of appropriate in-vivo animal testing is vital prior to clinical evaluations, since factors, such as wound fluid, growth factors, etc., need to be taken into account. When performing both of these types of evaluations (in vitro and in vivo), one also needs to be aware of which bacteria form is being studied, e.g., free floating (planktonic) or biofilm. This is especially critical, since bacteria living in a biofilm have been shown to be more resistant to therapies. The translation of in-vitro and in-vivo studies from the laboratory into the clinic is necessary to obtain successful antimicrobial therapeutics.

Original languageEnglish (US)
Pages (from-to)344-347
Number of pages4
JournalWounds
Volume16
Issue number11
StatePublished - Nov 1 2004

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

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