Development of a tissue phantom for experimental studies on Laser Interstitial ThermoTherapy of breast cancer

Nelson Salas, Fabrice Manns, Pascal Chapon, Peter Milne, Sergio Mendoza, David Denham, Jean-Marie A Parel, David Robinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

A tissue phantom for experimental studies in Laser Interstitial ThermoTherapy (LITT) for the treatment of small breast tumors was developed and evaluated. The tissue phantom consists of a polyacrylamide/acrylate hydrogel matrix containing various concentrations of an absorber (Nigrosin) and a scatterer (Intralipid 10% solution), allowing the optical properties to be varied in accordance to experimental need. Temperature measurements in the phantom were performed with a thermocouple array placed symmetrically around the fiber axis during laser irradiation for different output powers, treatment duration, and different concentrations of absorber. A 980 nm diode laser system was used in conjunction with an REM LightStic 360 diffusing tip fiber. The polyacrylamide/acrylate matrix tissue phantom remained stable during laser irradiation and produced reproducible results. The behavior of the temperature curves produced by the phantom during laser irradiation was similar to the behavior of the temperature curves in ex-vivo tissue. Therefore, this tissue phantom can be used as a model for the thermal response of tissue during laser interstitial thermotherapy. The phantom will be used as an experimental model to determine a set of optimum laser treatment parameters for laser interstitial thermotherapy of breast cancer.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages623-631
Number of pages9
Volume3907
StatePublished - 2000
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems X - San Jose, CA, USA
Duration: Jan 22 2000Jan 25 2000

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems X
CitySan Jose, CA, USA
Period1/22/001/25/00

Fingerprint

breast
interstitials
cancer
Tissue
Lasers
Laser beam effects
lasers
Polyacrylates
acrylates
irradiation
absorbers
Fibers
Thermocouples
fibers
Hydrogels
Temperature measurement
curves
thermocouples
matrices
Semiconductor lasers

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Salas, N., Manns, F., Chapon, P., Milne, P., Mendoza, S., Denham, D., ... Robinson, D. (2000). Development of a tissue phantom for experimental studies on Laser Interstitial ThermoTherapy of breast cancer. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3907, pp. 623-631). Society of Photo-Optical Instrumentation Engineers.

Development of a tissue phantom for experimental studies on Laser Interstitial ThermoTherapy of breast cancer. / Salas, Nelson; Manns, Fabrice; Chapon, Pascal; Milne, Peter; Mendoza, Sergio; Denham, David; Parel, Jean-Marie A; Robinson, David.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3907 Society of Photo-Optical Instrumentation Engineers, 2000. p. 623-631.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Salas, N, Manns, F, Chapon, P, Milne, P, Mendoza, S, Denham, D, Parel, J-MA & Robinson, D 2000, Development of a tissue phantom for experimental studies on Laser Interstitial ThermoTherapy of breast cancer. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3907, Society of Photo-Optical Instrumentation Engineers, pp. 623-631, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, San Jose, CA, USA, 1/22/00.
Salas N, Manns F, Chapon P, Milne P, Mendoza S, Denham D et al. Development of a tissue phantom for experimental studies on Laser Interstitial ThermoTherapy of breast cancer. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3907. Society of Photo-Optical Instrumentation Engineers. 2000. p. 623-631
Salas, Nelson ; Manns, Fabrice ; Chapon, Pascal ; Milne, Peter ; Mendoza, Sergio ; Denham, David ; Parel, Jean-Marie A ; Robinson, David. / Development of a tissue phantom for experimental studies on Laser Interstitial ThermoTherapy of breast cancer. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3907 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 623-631
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