Development of a nanomaterial based localized immunomodulatory and anti-inflammatory regimen to improve pancreatic islets transplantation

Diana Velluto, Teresa De Toni, Alice Tomei

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Decreasing local inflammation at the graft site will improve efficacy of islet transplantation in reversing diabetes and may decrease the dose of immunomodulatory drugs that are needed to prevent graft rejection. Localized immunomodulatory and anti-inflammatory (LISAI) platform improves drug solubility, stability, durability and site-targeting. We aim to develop a novel clinically applicable LISAI platform using nanomaterials with chemically customizable hydrophobicity for sustained and local delivery of anti-inflammatory drugs to improve islet transplantation in type-1 diabetes. We synthetized amphiphilic block copolymers made of poly(ethylene glycol)-poly(propylene sulfide) (PEG-PPS) and PEG-oligo(ethylene sulfide) (PEG-OES) that can self-assemble into solid core micelles and nanofibers and that display tunable drug encapsulation and release capacity. We demonstrated that these nanomaterials are non-immunogenic, non-toxic, and can traffic to lymph nodes (LNs) to target LN-resident immune cells. Here, we evaluated this nanomaterial platform as LISAI for loading and releasing dexamethasone (Dexa) and cyclosporine A (CsA) in the islet graft site by using recently optimized diabetes-relevant in vitro models.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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