Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka, Carol A. Westbrook, Marcy C. Speer, James M. Gilchrist, Ethylin W. Jabs, Elizabeth G. Schweins, Jeffrey M. Stajich, Perry C. Gaskell, Allen D. Roses, Margaret A Pericak-Vance

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalNeuromuscular Disorders
Volume4
Issue number5-6
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Interleukin-9
Limb-Girdle Muscular Dystrophies
Chromosomes, Human, Pair 5
Pedigree
Microsatellite Repeats
Chromosomes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. / Yamaoka, Larry H.; Westbrook, Carol A.; Speer, Marcy C.; Gilchrist, James M.; Jabs, Ethylin W.; Schweins, Elizabeth G.; Stajich, Jeffrey M.; Gaskell, Perry C.; Roses, Allen D.; Pericak-Vance, Margaret A.

In: Neuromuscular Disorders, Vol. 4, No. 5-6, 01.01.1994, p. 471-475.

Research output: Contribution to journal › Article

Yamaoka, LH, Westbrook, CA, Speer, MC, Gilchrist, JM, Jabs, EW, Schweins, EG, Stajich, JM, Gaskell, PC, Roses, AD & Pericak-Vance, MA 1994, 'Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9', Neuromuscular Disorders, vol. 4, no. 5-6, pp. 471-475. https://doi.org/10.1016/0960-8966(94)90086-8
Yamaoka LH, Westbrook CA, Speer MC, Gilchrist JM, Jabs EW, Schweins EG et al. Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscular Disorders. 1994 Jan 1;4(5-6):471-475. https://doi.org/10.1016/0960-8966(94)90086-8
Yamaoka, Larry H. ; Westbrook, Carol A. ; Speer, Marcy C. ; Gilchrist, James M. ; Jabs, Ethylin W. ; Schweins, Elizabeth G. ; Stajich, Jeffrey M. ; Gaskell, Perry C. ; Roses, Allen D. ; Pericak-Vance, Margaret A. / Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. In: Neuromuscular Disorders. 1994 ; Vol. 4, No. 5-6. pp. 471-475.
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