Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka; Carol A. Westbrook; Marcy C. Speer; James M. Gilchrist; Ethylin W. Jabs; Elizabeth G. Schweins; Jeffrey M. Stajich; Perry C. Gaskell; Allen D. Roses; Margaret A. Pericak-Vance

doi:10.1016/0960-8966(94)90086-8

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka, Carol A. Westbrook, Marcy C. Speer, James M. Gilchrist, Ethylin W. Jabs, Elizabeth G. Schweins, Jeffrey M. Stajich, Perry C. Gaskell, Allen D. Roses, Margaret A. Pericak-Vance

Research output: Contribution to journal › Article

25 Scopus citations

Abstract

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

Original language	English (US)
Pages (from-to)	471-475
Number of pages	5
Journal	Neuromuscular Disorders
Volume	4
Issue number	5-6
DOIs	https://doi.org/10.1016/0960-8966(94)90086-8
State	Published - Jan 1 1994
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neurology
Clinical Neurology
Genetics(clinical)

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10.1016/0960-8966(94)90086-8

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Yamaoka, L. H., Westbrook, C. A., Speer, M. C., Gilchrist, J. M., Jabs, E. W., Schweins, E. G., Stajich, J. M., Gaskell, P. C., Roses, A. D., & Pericak-Vance, M. A. (1994). Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscular Disorders, 4(5-6), 471-475. https://doi.org/10.1016/0960-8966(94)90086-8

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. / Yamaoka, Larry H.; Westbrook, Carol A.; Speer, Marcy C.; Gilchrist, James M.; Jabs, Ethylin W.; Schweins, Elizabeth G.; Stajich, Jeffrey M.; Gaskell, Perry C.; Roses, Allen D.; Pericak-Vance, Margaret A.

In: Neuromuscular Disorders, Vol. 4, No. 5-6, 01.01.1994, p. 471-475.

Research output: Contribution to journal › Article

Yamaoka, LH, Westbrook, CA, Speer, MC, Gilchrist, JM, Jabs, EW, Schweins, EG, Stajich, JM, Gaskell, PC, Roses, AD & Pericak-Vance, MA 1994, 'Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9', Neuromuscular Disorders, vol. 4, no. 5-6, pp. 471-475. https://doi.org/10.1016/0960-8966(94)90086-8

Yamaoka, Larry H. ; Westbrook, Carol A. ; Speer, Marcy C. ; Gilchrist, James M. ; Jabs, Ethylin W. ; Schweins, Elizabeth G. ; Stajich, Jeffrey M. ; Gaskell, Perry C. ; Roses, Allen D. ; Pericak-Vance, Margaret A. / Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. In: Neuromuscular Disorders. 1994 ; Vol. 4, No. 5-6. pp. 471-475.

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abstract = "Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.",

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