Abstract
Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.
| Original language | English |
|---|---|
| Pages (from-to) | 471-475 |
| Number of pages | 5 |
| Journal | Neuromuscular Disorders |
| Volume | 4 |
| Issue number | 5-6 |
| DOIs | |
| State | Published - Jan 1 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Developmental Neuroscience
- Neurology
Cite this
Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. / Yamaoka, Larry H.; Westbrook, Carol A.; Speer, Marcy C.; Gilchrist, James M.; Jabs, Ethylin W.; Schweins, Elizabeth G.; Stajich, Jeffrey M.; Gaskell, Perry C.; Roses, Allen D.; Pericak-Vance, Margaret A.
In: Neuromuscular Disorders, Vol. 4, No. 5-6, 01.01.1994, p. 471-475.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9
AU - Yamaoka, Larry H.
AU - Westbrook, Carol A.
AU - Speer, Marcy C.
AU - Gilchrist, James M.
AU - Jabs, Ethylin W.
AU - Schweins, Elizabeth G.
AU - Stajich, Jeffrey M.
AU - Gaskell, Perry C.
AU - Roses, Allen D.
AU - Pericak-Vance, Margaret A
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.
AB - Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.
UR - http://www.scopus.com/inward/record.url?scp=0027983965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027983965&partnerID=8YFLogxK
U2 - 10.1016/0960-8966(94)90086-8
DO - 10.1016/0960-8966(94)90086-8
M3 - Article
C2 - 7881291
AN - SCOPUS:0027983965
VL - 4
SP - 471
EP - 475
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
SN - 0960-8966
IS - 5-6
ER -