Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses

VISTA Steering Committees

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Introduction: Analysis of reliable registry data can direct future research to influence clinical care. Data from the Virtual International Stroke Trials Archive have been used to test hypotheses and inform trial design. We sought to expand Virtual International Stroke Trials Archive into a broader stroke resource with new opportunities for research and international collaboration. Methods: Using procedures initially developed for an acute stroke trial archive, we invited trialists to lodge data on rehabilitation, secondary prevention, intracerebral haemorrhage, imaging, and observational stroke studies. Results: We have extended Virtual International Stroke Trials Archive into six subsections: Virtual International Stroke Trials Archive-Acute (n=28190 patients' data), Virtual International Stroke Trials Archive-Rehab (n=10194), Virtual International Stroke Trials Archive-intracerebral haemorrhage (n=1829), Virtual International Stroke Trials Archive-Prevention, Virtual International Stroke Trials Archive-Imaging (n=1300), and Virtual International Stroke Trials Archive-Plus (n=6573). Enrollment continues, with commitments for the contribution of six further trials to Virtual International Stroke Trials Archive-Prevention, 13 trials to Virtual International Stroke Trials Archive-Rehab, and one registry to Virtual International Stroke Trials Archive-Plus. Data on age, type of stroke, medical history, outcomes by modified Rankin scale and Barthel Index (BI), mortality, and adverse events are available for analyses. The Virtual International Stroke Trials Archive network encourages the development of young investigators and provides opportunities for international peer review and collaboration. Conclusions: Application of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalInternational Journal of Stroke
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

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Stroke
Clinical Trials
Cerebral Hemorrhage
Research
Registries
Research Personnel
Intellectual Property
Peer Review
Secondary Prevention
Observational Studies

Keywords

  • Database
  • Secondary analysis
  • Stroke
  • Trial design

ASJC Scopus subject areas

  • Neurology

Cite this

Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses. / VISTA Steering Committees.

In: International Journal of Stroke, Vol. 7, No. 2, 01.02.2012, p. 133-138.

Research output: Contribution to journalArticle

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abstract = "Introduction: Analysis of reliable registry data can direct future research to influence clinical care. Data from the Virtual International Stroke Trials Archive have been used to test hypotheses and inform trial design. We sought to expand Virtual International Stroke Trials Archive into a broader stroke resource with new opportunities for research and international collaboration. Methods: Using procedures initially developed for an acute stroke trial archive, we invited trialists to lodge data on rehabilitation, secondary prevention, intracerebral haemorrhage, imaging, and observational stroke studies. Results: We have extended Virtual International Stroke Trials Archive into six subsections: Virtual International Stroke Trials Archive-Acute (n=28190 patients' data), Virtual International Stroke Trials Archive-Rehab (n=10194), Virtual International Stroke Trials Archive-intracerebral haemorrhage (n=1829), Virtual International Stroke Trials Archive-Prevention, Virtual International Stroke Trials Archive-Imaging (n=1300), and Virtual International Stroke Trials Archive-Plus (n=6573). Enrollment continues, with commitments for the contribution of six further trials to Virtual International Stroke Trials Archive-Prevention, 13 trials to Virtual International Stroke Trials Archive-Rehab, and one registry to Virtual International Stroke Trials Archive-Plus. Data on age, type of stroke, medical history, outcomes by modified Rankin scale and Barthel Index (BI), mortality, and adverse events are available for analyses. The Virtual International Stroke Trials Archive network encourages the development of young investigators and provides opportunities for international peer review and collaboration. Conclusions: Application of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas.",
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AU - VISTA Steering Committees

AU - Ali, Myzoon

AU - Bath, Philip

AU - Brady, Marian

AU - Davis, Stephen

AU - Diener, Hans Christoph

AU - Donnan, Geoffrey

AU - Fisher, Marc

AU - Hacke, Werner

AU - Hanley, Daniel F.

AU - Luby, Marie

AU - Tsivgoulis, G.

AU - Wahlgren, Nils

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AU - Lees, Kennedy R.

AU - Lees, K. R.

AU - Alexandrov, A.

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AU - Bluhmki, E.

AU - Claesson, L.

AU - Davis, S. M.

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AU - Diener, H. C.

AU - Fisher, M.

AU - Gregson, B.

AU - Grotta, J.

AU - Hacke, W.

AU - Hennerici, M. G.

AU - Sacco, Ralph L

AU - Kaste, M.

AU - Lyden, P.

AU - Marler, J.

AU - Muir, K.

AU - Sacco, R.

AU - Shuaib, A.

AU - Teal, P.

AU - Wahlgren, N. G.

AU - Warach, S.

AU - Weimar, C.

AU - Brady, M.

AU - Ali, M.

AU - Ashburn, A.

AU - Barer, D.

AU - Bowen, A.

AU - Brodie, E.

AU - Corr, S.

AU - Drummond, A.

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KW - Stroke

KW - Trial design

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