Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia

Charlotte Nys, Colin R. Janssen, Edward M. Mager, Andrew J. Esbaugh, Kevin V. Brix, Martin Grosell, William A. Stubblefield, Keith Holtze, Karel A C De Schamphelaere

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

While it is increasingly being recognized that biotic ligand models (BLMs) are valuable in the risk assessment of metals in aquatic systems, the development of chronic BLMs has been less advanced for lead than for other metals. The authors investigated the univariate effects of Ca and pH on the chronic reproductive toxicity of Pb to Ceriodaphnia dubia at 4 levels. Calcium influenced chronic Pb toxicity to C. dubia only to a relatively small extent, whereas a high pH (8.2) provided strong protection against Pb toxicity (compared with lower pH levels). Based on this data set, a chronic Pb BLM for C. dubia was developed. The effect of pH was modeled as a single biotic ligand site competition by H+ with a log stability constant for binding of H+ to the biotic ligand (KHBL) of 7.6, while no other competitive constants were needed. The developed BLM was shown, in an independent validation with 3 other data sets, to be capable of predicting chronic Pb toxicity to different clones of C. dubia by an error of less than a factor of 2 in most synthetic and natural waters considered. The results add to the growing evidence that BLM-based risk assessment or water-quality criteria for Pb are likely to be more appropriate relative to hardness-based assessments or criteria.

Original languageEnglish
Pages (from-to)394-403
Number of pages10
JournalEnvironmental Toxicology and Chemistry
Volume33
Issue number2
DOIs
StatePublished - Feb 1 2014

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ligand
Toxicity
toxicity
Ligands
Risk assessment
risk assessment
Metals
Water Quality
metal
Hardness
hardness
Water quality
clone
Clone Cells
calcium
Calcium
water quality
Water

Keywords

  • Biotic ligand model
  • Daphnia
  • Metal bioavailability
  • Risk assessment
  • Water-quality criteria

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Environmental Chemistry

Cite this

Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia. / Nys, Charlotte; Janssen, Colin R.; Mager, Edward M.; Esbaugh, Andrew J.; Brix, Kevin V.; Grosell, Martin; Stubblefield, William A.; Holtze, Keith; De Schamphelaere, Karel A C.

In: Environmental Toxicology and Chemistry, Vol. 33, No. 2, 01.02.2014, p. 394-403.

Research output: Contribution to journalArticle

Nys, C, Janssen, CR, Mager, EM, Esbaugh, AJ, Brix, KV, Grosell, M, Stubblefield, WA, Holtze, K & De Schamphelaere, KAC 2014, 'Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia', Environmental Toxicology and Chemistry, vol. 33, no. 2, pp. 394-403. https://doi.org/10.1002/etc.2433
Nys, Charlotte ; Janssen, Colin R. ; Mager, Edward M. ; Esbaugh, Andrew J. ; Brix, Kevin V. ; Grosell, Martin ; Stubblefield, William A. ; Holtze, Keith ; De Schamphelaere, Karel A C. / Development and validation of a biotic ligand model for predicting chronic toxicity of lead to Ceriodaphnia dubia. In: Environmental Toxicology and Chemistry. 2014 ; Vol. 33, No. 2. pp. 394-403.
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