Development and reversibility of aluminum-induced bone lesion in the rat

S. M. Ott, E. Feist, D. L. Andress, C. C. Liu, D. J. Sherrard, A. C. Alfrey, E. Slatopolsky, Guy Howard

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We studied the effect of aluminum injections on bones of rats after intervals of 3, 6 and 9 weeks. To study reversibility, we allowed one group to recover for 3 weeks. Both weanling and adult rats were examined to determine the influence of age. The calcium, phosphate, creatinine, and parathyroid hormone levels were similar in aluminum-treated rats and controls. Aluminum could be seen by histochemical stain after 6 weeks, but at that time the bone was otherwise normal. By 9 weeks the bone formation (as measured by tetracycline labeling) in aluminum-treated rats was severely decreased on trabecular and endosteal surfaces. The periosteal surfaces showed normal formation. After 3 weeks of recovery, the bone formation rate in the young aluminum-treated rats was similar to that in the controls, although the serum and bone aluminum values had not significantly decreased. A higher percentage of aluminum was seen in the cement lines. In the adult rats, the bones had more stainable aluminum, and increased osteoid was noted along trabecular and periosteal surfaces. The doses of aluminum used in these rats greatly exceeded those that cause toxicity in humans; thus these findings may not directly apply to clinical practice. We conclude that aluminum administration can lead to decreased rates of bone formation in the rat, despite normal calcium level and renal function, and without decreased parathyroid hormone levels. The peritoneal route of administration could also have contributed to bone lesions by causing peritonitis, malabsorption, or both. Adult rats showed signs of early osteomalacia. Aluminum accumulates in the bone before the bone formation rate decreases. The abnormalities are not seen on the periosteal surfaces, suggesting that local factors may play a role in aluminum toxicity. The lesion is reversible when aluminum loading ceases.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalJournal of Laboratory and Clinical Medicine
Volume109
Issue number1
StatePublished - Mar 17 1987
Externally publishedYes

Fingerprint

Aluminum
Rats
Bone
Bone and Bones
Osteogenesis
Parathyroid Hormone
Toxicity
Bone cement
Osteomalacia
Tetracycline
Peritonitis
Labeling
Creatinine
Coloring Agents
Calcium
Kidney

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Ott, S. M., Feist, E., Andress, D. L., Liu, C. C., Sherrard, D. J., Alfrey, A. C., ... Howard, G. (1987). Development and reversibility of aluminum-induced bone lesion in the rat. Journal of Laboratory and Clinical Medicine, 109(1), 40-47.

Development and reversibility of aluminum-induced bone lesion in the rat. / Ott, S. M.; Feist, E.; Andress, D. L.; Liu, C. C.; Sherrard, D. J.; Alfrey, A. C.; Slatopolsky, E.; Howard, Guy.

In: Journal of Laboratory and Clinical Medicine, Vol. 109, No. 1, 17.03.1987, p. 40-47.

Research output: Contribution to journalArticle

Ott, SM, Feist, E, Andress, DL, Liu, CC, Sherrard, DJ, Alfrey, AC, Slatopolsky, E & Howard, G 1987, 'Development and reversibility of aluminum-induced bone lesion in the rat', Journal of Laboratory and Clinical Medicine, vol. 109, no. 1, pp. 40-47.
Ott SM, Feist E, Andress DL, Liu CC, Sherrard DJ, Alfrey AC et al. Development and reversibility of aluminum-induced bone lesion in the rat. Journal of Laboratory and Clinical Medicine. 1987 Mar 17;109(1):40-47.
Ott, S. M. ; Feist, E. ; Andress, D. L. ; Liu, C. C. ; Sherrard, D. J. ; Alfrey, A. C. ; Slatopolsky, E. ; Howard, Guy. / Development and reversibility of aluminum-induced bone lesion in the rat. In: Journal of Laboratory and Clinical Medicine. 1987 ; Vol. 109, No. 1. pp. 40-47.
@article{8c0a1026d00c4a9b9981bb0f68bf0cc0,
title = "Development and reversibility of aluminum-induced bone lesion in the rat",
abstract = "We studied the effect of aluminum injections on bones of rats after intervals of 3, 6 and 9 weeks. To study reversibility, we allowed one group to recover for 3 weeks. Both weanling and adult rats were examined to determine the influence of age. The calcium, phosphate, creatinine, and parathyroid hormone levels were similar in aluminum-treated rats and controls. Aluminum could be seen by histochemical stain after 6 weeks, but at that time the bone was otherwise normal. By 9 weeks the bone formation (as measured by tetracycline labeling) in aluminum-treated rats was severely decreased on trabecular and endosteal surfaces. The periosteal surfaces showed normal formation. After 3 weeks of recovery, the bone formation rate in the young aluminum-treated rats was similar to that in the controls, although the serum and bone aluminum values had not significantly decreased. A higher percentage of aluminum was seen in the cement lines. In the adult rats, the bones had more stainable aluminum, and increased osteoid was noted along trabecular and periosteal surfaces. The doses of aluminum used in these rats greatly exceeded those that cause toxicity in humans; thus these findings may not directly apply to clinical practice. We conclude that aluminum administration can lead to decreased rates of bone formation in the rat, despite normal calcium level and renal function, and without decreased parathyroid hormone levels. The peritoneal route of administration could also have contributed to bone lesions by causing peritonitis, malabsorption, or both. Adult rats showed signs of early osteomalacia. Aluminum accumulates in the bone before the bone formation rate decreases. The abnormalities are not seen on the periosteal surfaces, suggesting that local factors may play a role in aluminum toxicity. The lesion is reversible when aluminum loading ceases.",
author = "Ott, {S. M.} and E. Feist and Andress, {D. L.} and Liu, {C. C.} and Sherrard, {D. J.} and Alfrey, {A. C.} and E. Slatopolsky and Guy Howard",
year = "1987",
month = "3",
day = "17",
language = "English",
volume = "109",
pages = "40--47",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",
number = "1",

}

TY - JOUR

T1 - Development and reversibility of aluminum-induced bone lesion in the rat

AU - Ott, S. M.

AU - Feist, E.

AU - Andress, D. L.

AU - Liu, C. C.

AU - Sherrard, D. J.

AU - Alfrey, A. C.

AU - Slatopolsky, E.

AU - Howard, Guy

PY - 1987/3/17

Y1 - 1987/3/17

N2 - We studied the effect of aluminum injections on bones of rats after intervals of 3, 6 and 9 weeks. To study reversibility, we allowed one group to recover for 3 weeks. Both weanling and adult rats were examined to determine the influence of age. The calcium, phosphate, creatinine, and parathyroid hormone levels were similar in aluminum-treated rats and controls. Aluminum could be seen by histochemical stain after 6 weeks, but at that time the bone was otherwise normal. By 9 weeks the bone formation (as measured by tetracycline labeling) in aluminum-treated rats was severely decreased on trabecular and endosteal surfaces. The periosteal surfaces showed normal formation. After 3 weeks of recovery, the bone formation rate in the young aluminum-treated rats was similar to that in the controls, although the serum and bone aluminum values had not significantly decreased. A higher percentage of aluminum was seen in the cement lines. In the adult rats, the bones had more stainable aluminum, and increased osteoid was noted along trabecular and periosteal surfaces. The doses of aluminum used in these rats greatly exceeded those that cause toxicity in humans; thus these findings may not directly apply to clinical practice. We conclude that aluminum administration can lead to decreased rates of bone formation in the rat, despite normal calcium level and renal function, and without decreased parathyroid hormone levels. The peritoneal route of administration could also have contributed to bone lesions by causing peritonitis, malabsorption, or both. Adult rats showed signs of early osteomalacia. Aluminum accumulates in the bone before the bone formation rate decreases. The abnormalities are not seen on the periosteal surfaces, suggesting that local factors may play a role in aluminum toxicity. The lesion is reversible when aluminum loading ceases.

AB - We studied the effect of aluminum injections on bones of rats after intervals of 3, 6 and 9 weeks. To study reversibility, we allowed one group to recover for 3 weeks. Both weanling and adult rats were examined to determine the influence of age. The calcium, phosphate, creatinine, and parathyroid hormone levels were similar in aluminum-treated rats and controls. Aluminum could be seen by histochemical stain after 6 weeks, but at that time the bone was otherwise normal. By 9 weeks the bone formation (as measured by tetracycline labeling) in aluminum-treated rats was severely decreased on trabecular and endosteal surfaces. The periosteal surfaces showed normal formation. After 3 weeks of recovery, the bone formation rate in the young aluminum-treated rats was similar to that in the controls, although the serum and bone aluminum values had not significantly decreased. A higher percentage of aluminum was seen in the cement lines. In the adult rats, the bones had more stainable aluminum, and increased osteoid was noted along trabecular and periosteal surfaces. The doses of aluminum used in these rats greatly exceeded those that cause toxicity in humans; thus these findings may not directly apply to clinical practice. We conclude that aluminum administration can lead to decreased rates of bone formation in the rat, despite normal calcium level and renal function, and without decreased parathyroid hormone levels. The peritoneal route of administration could also have contributed to bone lesions by causing peritonitis, malabsorption, or both. Adult rats showed signs of early osteomalacia. Aluminum accumulates in the bone before the bone formation rate decreases. The abnormalities are not seen on the periosteal surfaces, suggesting that local factors may play a role in aluminum toxicity. The lesion is reversible when aluminum loading ceases.

UR - http://www.scopus.com/inward/record.url?scp=0023086321&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023086321&partnerID=8YFLogxK

M3 - Article

C2 - 3794513

AN - SCOPUS:0023086321

VL - 109

SP - 40

EP - 47

JO - Translational Research

JF - Translational Research

SN - 1931-5244

IS - 1

ER -