Development and comparison of machine learning algorithms to determine visual field progression

Osamah Saeedi, Michael V. Boland, Loris D’acunto, Ramya Swamy, Vikram Hegde, Surabhi Gupta, Amin Venjara, Joby Tsai, Jonathan S. Myers, Sarah R. Wellik, Gustavo Demoraes, Louis R. Pasquale, Lucy Q. Shen, Yangjiani Li, Tobias Elze

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Purpose: To develop and test machine learning classifiers (MLCs) for determining visual field progression. Methods: In total, 90,713 visual fields from 13,156 eyes were included. Six different progression algorithms (linear regression of mean deviation, linear regression of the visual field index, Advanced Glaucoma Intervention Study algorithm, Collaborative Initial Glaucoma Treatment Study algorithm, pointwise linear regression [PLR], and permutation of PLR) were applied to classify each eye as progressing or stable. Six MLCs were applied (logistic regression, random forest, extreme gradient boosting, support vector classifier, convolutional neural network, fully connected neural network) using a training and testing set. For MLC input, visual fields for a given eye were divided into the first and second half and each location averaged over time within each half. Each algorithm was tested for accuracy, sensitivity, positive predictive value, and class bias with a subset of visual fields labeled by a panel of three experts from 161 eyes. Results: MLCs had similar performance metrics as some of the conventional algorithms and ranged from 87% to 91% accurate with sensitivity ranging from 0.83 to 0.88 and specificity from 0.92 to 0.96. All conventional algorithms showed significant class bias, meaning each individual algorithm was more likely to grade uncertain cases as either progressing or stable (P ≤ 0.01). Conversely, all MLCs were balanced, meaning they were equally likely to grade uncertain cases as either progressing or stable (P ≥ 0.08). Conclusions: MLCs showed a moderate to high level of accuracy, sensitivity, and specificity and were more balanced than conventional algorithms. Translational Relevance: MLCs may help to determine visual field progression.

Original languageEnglish (US)
Article number27
JournalTranslational Vision Science and Technology
Volume10
Issue number7
DOIs
StatePublished - 2021

Keywords

  • Glaucoma
  • Machine learning
  • Visual fields

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

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