@article{60f3b215ee29480fb858f6576f36f647,
title = "Developing a potential retinal OCT biomarker for local growth of geographic atrophy",
abstract = "Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.",
author = "Yue Yu and Moult, {Eric M.} and Siyu Chen and Qiushi Ren and Rosenfeld, {Philip J.} and Waheed, {Nadia K.} and Fujimoto, {James G.}",
note = "Funding Information: China Scholarship Council (201806010297); National Institutes of Health (5-R01-EY011289-31); Topcon Corporation; Retina Research Foundation; Beckman Argyros Award in Vision Research; Ant{\'o}nio Champalimaud Vision Award; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation. Funding Information: China Scholarship Council (201806010297); National Institutes of Health (5-R01-EY011289-31); Topcon Corporation; Retina Research Foundation; Beckman Argyros Award in Vision Research; Ant?nio Champalimaud Vision Award; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation. Publisher Copyright: {\textcopyright} 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement",
year = "2020",
month = sep,
day = "1",
doi = "10.1364/BOE.399506",
language = "English (US)",
volume = "11",
pages = "5181--5196",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "9",
}