Developing a potential retinal OCT biomarker for local growth of geographic atrophy

Yue Yu; Eric M. Moult; Siyu Chen; Qiushi Ren; Philip J. Rosenfeld; Nadia K. Waheed; James G. Fujimoto

doi:10.1364/BOE.399506

Developing a potential retinal OCT biomarker for local growth of geographic atrophy

Yue Yu, Eric M. Moult, Siyu Chen, Qiushi Ren, Philip J. Rosenfeld, Nadia K. Waheed, James G. Fujimoto

Ophthalmology

Research output: Contribution to journal › Article › peer-review

Abstract

Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.

Original language	English (US)
Pages (from-to)	5181-5196
Number of pages	16
Journal	Biomedical Optics Express
Volume	11
Issue number	9
DOIs	https://doi.org/10.1364/BOE.399506
State	Published - Sep 1 2020

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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title = "Developing a potential retinal OCT biomarker for local growth of geographic atrophy",

abstract = "Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.",

author = "Yue Yu and Moult, {Eric M.} and Siyu Chen and Qiushi Ren and Rosenfeld, {Philip J.} and Waheed, {Nadia K.} and Fujimoto, {James G.}",

note = "Funding Information: China Scholarship Council (201806010297); National Institutes of Health (5-R01-EY011289-31); Topcon Corporation; Retina Research Foundation; Beckman Argyros Award in Vision Research; Ant{\'o}nio Champalimaud Vision Award; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation. Funding Information: China Scholarship Council (201806010297); National Institutes of Health (5-R01-EY011289-31); Topcon Corporation; Retina Research Foundation; Beckman Argyros Award in Vision Research; Ant?nio Champalimaud Vision Award; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation.",

year = "2020",

month = sep,

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doi = "10.1364/BOE.399506",

language = "English (US)",

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T1 - Developing a potential retinal OCT biomarker for local growth of geographic atrophy

AU - Yu, Yue

AU - Moult, Eric M.

AU - Chen, Siyu

AU - Ren, Qiushi

AU - Rosenfeld, Philip J.

AU - Waheed, Nadia K.

AU - Fujimoto, James G.

N1 - Funding Information: China Scholarship Council (201806010297); National Institutes of Health (5-R01-EY011289-31); Topcon Corporation; Retina Research Foundation; Beckman Argyros Award in Vision Research; António Champalimaud Vision Award; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation. Funding Information: China Scholarship Council (201806010297); National Institutes of Health (5-R01-EY011289-31); Topcon Corporation; Retina Research Foundation; Beckman Argyros Award in Vision Research; Ant?nio Champalimaud Vision Award; Massachusetts Lions Eye Research Fund; Macula Vision Research Foundation.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.

AB - Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies.

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