Developing a neonatal acute kidney injury research definition

A report from the NIDDK neonatal AKI workshop

Michael Zappitelli, Namasivayam Ambalavanan, David J. Askenazi, Marva M. Moxey-Mims, Paul L. Kimmel, Robert A. Star, Carolyn Abitbol, Patrick D. Brophy, Guillermo Hidalgo, Mina Hanna, Catherine M. Morgan, Tonse N.K. Raju, Patricio Ray, Zayhara Reyes-Bou, Amani Roushdi, Stuart L. Goldstein

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Research on neonatal AKI definition is evolving and must consider physiology (e.g., developmental GFR increase) while allowing for flexibility to include future validated markers of structural/tissue injury. Neonatal AKI definitions will enable rigorous clinical and translational research. A summary of research recommendations and knowledge gaps is provided in Table 2. Multicenter studies (such as The Neonatal Kidney Collaborative group, formed subsequent to this NIH workshop) to address these knowledge gaps and determine definitions that are most feasible and best predict outcomes are needed (4). Until a widely accepted definition is available, researchers should strive to use rational, physiology-based SCr and urine output definition criteria and clearly describe methods used to define neonatal AKI, in published data, in order to move this field forward.

Original languageEnglish (US)
Pages (from-to)569-573
Number of pages5
JournalPediatric Research
Volume82
Issue number4
DOIs
StatePublished - Oct 1 2017

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National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Acute Kidney Injury
Education
Translational Medical Research
Research
Multicenter Studies
Research Personnel
Urine
Kidney
Wounds and Injuries

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Zappitelli, M., Ambalavanan, N., Askenazi, D. J., Moxey-Mims, M. M., Kimmel, P. L., Star, R. A., ... Goldstein, S. L. (2017). Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop. Pediatric Research, 82(4), 569-573. https://doi.org/10.1038/pr.2017.136

Developing a neonatal acute kidney injury research definition : A report from the NIDDK neonatal AKI workshop. / Zappitelli, Michael; Ambalavanan, Namasivayam; Askenazi, David J.; Moxey-Mims, Marva M.; Kimmel, Paul L.; Star, Robert A.; Abitbol, Carolyn; Brophy, Patrick D.; Hidalgo, Guillermo; Hanna, Mina; Morgan, Catherine M.; Raju, Tonse N.K.; Ray, Patricio; Reyes-Bou, Zayhara; Roushdi, Amani; Goldstein, Stuart L.

In: Pediatric Research, Vol. 82, No. 4, 01.10.2017, p. 569-573.

Research output: Contribution to journalArticle

Zappitelli, M, Ambalavanan, N, Askenazi, DJ, Moxey-Mims, MM, Kimmel, PL, Star, RA, Abitbol, C, Brophy, PD, Hidalgo, G, Hanna, M, Morgan, CM, Raju, TNK, Ray, P, Reyes-Bou, Z, Roushdi, A & Goldstein, SL 2017, 'Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop', Pediatric Research, vol. 82, no. 4, pp. 569-573. https://doi.org/10.1038/pr.2017.136
Zappitelli M, Ambalavanan N, Askenazi DJ, Moxey-Mims MM, Kimmel PL, Star RA et al. Developing a neonatal acute kidney injury research definition: A report from the NIDDK neonatal AKI workshop. Pediatric Research. 2017 Oct 1;82(4):569-573. https://doi.org/10.1038/pr.2017.136
Zappitelli, Michael ; Ambalavanan, Namasivayam ; Askenazi, David J. ; Moxey-Mims, Marva M. ; Kimmel, Paul L. ; Star, Robert A. ; Abitbol, Carolyn ; Brophy, Patrick D. ; Hidalgo, Guillermo ; Hanna, Mina ; Morgan, Catherine M. ; Raju, Tonse N.K. ; Ray, Patricio ; Reyes-Bou, Zayhara ; Roushdi, Amani ; Goldstein, Stuart L. / Developing a neonatal acute kidney injury research definition : A report from the NIDDK neonatal AKI workshop. In: Pediatric Research. 2017 ; Vol. 82, No. 4. pp. 569-573.
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