Devastating intracardiac and aortic thrombosis: A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation

Edward Gologorsky, David M. Andrews, Angela Gologorsky, Venkata Sampathi, Lalitha Sundararaman, Radhika Govindaswamy, Yehuda Raveh, Andreas G. Tzakis, Ernesto A. Pretto

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Fewer than 80 cases of intracardiac thrombosis and intraoperative pulmonary thromboembolism during liver transplantation have been described. We present a patient who suffered an intraoperative fulminant intracardiac and aortic thrombosis and posthumously was found to have had high anticardiolipin immunoglobulin M concentration and markers of hyperfibrinolysis in preoperatively collected plasma. Hemostatic therapy in the presence of circulating antiphospholipid antibodies and the pathogenesis of a catastrophic antiphospholipid syndrome are discussed.

Original languageEnglish (US)
Pages (from-to)398-402
Number of pages5
JournalJournal of Clinical Anesthesia
Volume23
Issue number5
DOIs
StatePublished - Aug 1 2011

Keywords

  • Antiphospholipid syndrome
  • Aortic thrombosis
  • Hemostatic therapy
  • Intracardiac thrombosis
  • Intraoperative pulmonary thromboembolism
  • Liver transplantation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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