Devastating intracardiac and aortic thrombosis: A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation

Edward Gologorsky; David M. Andrews; Angela Gologorsky; Venkata Sampathi; Lalitha Sundararaman; Radhika Govindaswamy; Yehuda Raveh; Andreas G. Tzakis; Ernesto A. Pretto

doi:10.1016/j.jclinane.2010.07.007

Devastating intracardiac and aortic thrombosis: A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation

Edward Gologorsky, David M. Andrews, Angela Gologorsky, Venkata Sampathi, Lalitha Sundararaman, Radhika Govindaswamy, Yehuda Raveh, Andreas G. Tzakis, Ernesto A. Pretto

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Fewer than 80 cases of intracardiac thrombosis and intraoperative pulmonary thromboembolism during liver transplantation have been described. We present a patient who suffered an intraoperative fulminant intracardiac and aortic thrombosis and posthumously was found to have had high anticardiolipin immunoglobulin M concentration and markers of hyperfibrinolysis in preoperatively collected plasma. Hemostatic therapy in the presence of circulating antiphospholipid antibodies and the pathogenesis of a catastrophic antiphospholipid syndrome are discussed.

Original language	English (US)
Pages (from-to)	398-402
Number of pages	5
Journal	Journal of Clinical Anesthesia
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.jclinane.2010.07.007
State	Published - Aug 2011

Keywords

Antiphospholipid syndrome
Aortic thrombosis
Hemostatic therapy
Intracardiac thrombosis
Intraoperative pulmonary thromboembolism
Liver transplantation

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1016/j.jclinane.2010.07.007

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Gologorsky, E., Andrews, D. M., Gologorsky, A., Sampathi, V., Sundararaman, L., Govindaswamy, R., Raveh, Y., Tzakis, A. G., & Pretto, E. A. (2011). Devastating intracardiac and aortic thrombosis: A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation. Journal of Clinical Anesthesia, 23(5), 398-402. https://doi.org/10.1016/j.jclinane.2010.07.007

Devastating intracardiac and aortic thrombosis : A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation. / Gologorsky, Edward; Andrews, David M.; Gologorsky, Angela; Sampathi, Venkata; Sundararaman, Lalitha; Govindaswamy, Radhika; Raveh, Yehuda; Tzakis, Andreas G.; Pretto, Ernesto A.

In: Journal of Clinical Anesthesia, Vol. 23, No. 5, 08.2011, p. 398-402.

Research output: Contribution to journal › Article › peer-review

Gologorsky, E, Andrews, DM, Gologorsky, A, Sampathi, V, Sundararaman, L, Govindaswamy, R, Raveh, Y, Tzakis, AG & Pretto, EA 2011, 'Devastating intracardiac and aortic thrombosis: A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation', Journal of Clinical Anesthesia, vol. 23, no. 5, pp. 398-402. https://doi.org/10.1016/j.jclinane.2010.07.007

Gologorsky, Edward ; Andrews, David M. ; Gologorsky, Angela ; Sampathi, Venkata ; Sundararaman, Lalitha ; Govindaswamy, Radhika ; Raveh, Yehuda ; Tzakis, Andreas G. ; Pretto, Ernesto A. / Devastating intracardiac and aortic thrombosis : A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation. In: Journal of Clinical Anesthesia. 2011 ; Vol. 23, No. 5. pp. 398-402.

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abstract = "Fewer than 80 cases of intracardiac thrombosis and intraoperative pulmonary thromboembolism during liver transplantation have been described. We present a patient who suffered an intraoperative fulminant intracardiac and aortic thrombosis and posthumously was found to have had high anticardiolipin immunoglobulin M concentration and markers of hyperfibrinolysis in preoperatively collected plasma. Hemostatic therapy in the presence of circulating antiphospholipid antibodies and the pathogenesis of a catastrophic antiphospholipid syndrome are discussed.",

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AB - Fewer than 80 cases of intracardiac thrombosis and intraoperative pulmonary thromboembolism during liver transplantation have been described. We present a patient who suffered an intraoperative fulminant intracardiac and aortic thrombosis and posthumously was found to have had high anticardiolipin immunoglobulin M concentration and markers of hyperfibrinolysis in preoperatively collected plasma. Hemostatic therapy in the presence of circulating antiphospholipid antibodies and the pathogenesis of a catastrophic antiphospholipid syndrome are discussed.

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Devastating intracardiac and aortic thrombosis: A case report of apparent catastrophic antiphospholipid syndrome during liver transplantation

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