Determining the properties of gene regulatory networks from expression data

Larry S. Liebovitch, Lina A. Shehadeh, Viktor K. Jirsa, Marc Thorsten Hütt, Carsten Marr

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The expression of genes depends on the physical structure of DNA, how the function of DNA is regulated by the transcription factors expressed by other genes, RNA regulation, such as that through RNA interference, and protein signals mediated by protein-protein interaction networks. We illustrate different approaches to determining information about the network of gene regulation from experimental data. First, we show that we can use statistical information of the mRNA expression values to determine the global topological properties of the gene regulatory network. Second, we show that analyzing the changes in expression due to mutations or different environmental conditions can give us information on the relative importance of the different mechanisms involved in gene regulation.

Original languageEnglish (US)
Title of host publicationHandbook of Research on Computational Methodologies in Gene Regulatory Networks
PublisherIGI Global
Pages405-428
Number of pages24
ISBN (Print)9781605666853
DOIs
StatePublished - Dec 1 2009

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ASJC Scopus subject areas

  • Health Professions(all)

Cite this

Liebovitch, L. S., Shehadeh, L. A., Jirsa, V. K., Hütt, M. T., & Marr, C. (2009). Determining the properties of gene regulatory networks from expression data. In Handbook of Research on Computational Methodologies in Gene Regulatory Networks (pp. 405-428). IGI Global. https://doi.org/10.4018/978-1-60566-685-3.ch017