Mice lacking the v(α(1,3/Hλ1) gene do not produce a λ1 anti-α(1,3) dextran response. However, on hyperimmunization some strains mount a Kappa-anti-α(1,3) dextran response, whereas others remain nonresponder. Responsiveness is dominant. The Kappa-anti-α(1,3) response difference is linked to the Ly-3 locus on chromosome 6 and is likely the result of a structural v(Kappa)-gene(s). In conjunction with previous work, three v(Kappa)-allogroups can now be distinguished. At present, this is the only example of an immune responsiveness difference associated with the v(Kappa)-locus.
ASJC Scopus subject areas
- Immunology and Allergy