Determination of the kappa anti-α(1,3) dextran immune response difference by a gene(s) in the vx-locus of mice*

Claude De Preval, Bonnie Blomberg, Melvin Cohn

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Mice lacking the v(α(1,3/Hλ1) gene do not produce a λ1 anti-α(1,3) dextran response. However, on hyperimmunization some strains mount a Kappa-anti-α(1,3) dextran response, whereas others remain nonresponder. Responsiveness is dominant. The Kappa-anti-α(1,3) response difference is linked to the Ly-3 locus on chromosome 6 and is likely the result of a structural v(Kappa)-gene(s). In conjunction with previous work, three v(Kappa)-allogroups can now be distinguished. At present, this is the only example of an immune responsiveness difference associated with the v(Kappa)-locus.

Original languageEnglish (US)
Pages (from-to)1265-1270
Number of pages6
JournalJournal of Experimental Medicine
Volume149
Issue number5
DOIs
StatePublished - May 1 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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