Determination of the Ischemic Threshold for Brain Oxygen Tension

E. M R Doppenberg, A. Zauner, J. C. Watson, Ross Bullock

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Measuring brain tissue oxygenation is now possible due to major advances in the technical development of Clark-electrodes and fiberoptic systems. However, to make this technique clinically useful for both nurses and medical staff, the ischemic threshold for brain tissue oxygen tension (brain pO2) must be determined. Three end points were used for determination of the critical brain pO2 value. 1) Infarct determination after permanent middle cerebral artery occlusion in a feline model. 2) Threshold analysis using the schemic threshold for cerebral blood flow (CBF) as a "gold standard" in severely head injury patients. 3) Outcome analysis in severely head injured patients. Brain pO2 dropped to 19±6mmHg and 23 ± 6, 4 to 5 hours after MCA occlusion in the cat (n = 12). In severely head injured patients, a brain pO2 ≤ 19mmHg was correlated with poor outcome (n = 24). The ischemic threshold for (r)CBF of 18ml/100g/min corresponded to a brain pO2 of 22mmHg, in the same patients. By using the above mentioned end points as a reference, we found the critical value for brain pO2 to be in between 19 and 23mmHg. Clearly, the difference between our threshold value and the lower critical brain pO2 level found by other groups using the Licox system, needs to be clarified in a comparison study before a uniform threshold for brain pO2 can be determined.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalActa Neurochirurgica, Supplement
Volume1998
Issue numberSUPPL. 71
StatePublished - Dec 1 1998
Externally publishedYes

Fingerprint

oxygen tension
brain
Brain
Oxygen
thresholds
Cerebrovascular Circulation
occlusion
blood flow
Blood
Head
Tissue
Oxygenation
Middle Cerebral Artery Infarction
oxygenation
cats
Medical Staff
Felidae
arteries
Craniocerebral Trauma
Electrodes

Keywords

  • Brain oxygen tension
  • Clark-electrodes
  • Ischemic threshold
  • Middle cerebral artery occlusion

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Doppenberg, E. M. R., Zauner, A., Watson, J. C., & Bullock, R. (1998). Determination of the Ischemic Threshold for Brain Oxygen Tension. Acta Neurochirurgica, Supplement, 1998(SUPPL. 71), 166-169.

Determination of the Ischemic Threshold for Brain Oxygen Tension. / Doppenberg, E. M R; Zauner, A.; Watson, J. C.; Bullock, Ross.

In: Acta Neurochirurgica, Supplement, Vol. 1998, No. SUPPL. 71, 01.12.1998, p. 166-169.

Research output: Contribution to journalArticle

Doppenberg, EMR, Zauner, A, Watson, JC & Bullock, R 1998, 'Determination of the Ischemic Threshold for Brain Oxygen Tension', Acta Neurochirurgica, Supplement, vol. 1998, no. SUPPL. 71, pp. 166-169.
Doppenberg EMR, Zauner A, Watson JC, Bullock R. Determination of the Ischemic Threshold for Brain Oxygen Tension. Acta Neurochirurgica, Supplement. 1998 Dec 1;1998(SUPPL. 71):166-169.
Doppenberg, E. M R ; Zauner, A. ; Watson, J. C. ; Bullock, Ross. / Determination of the Ischemic Threshold for Brain Oxygen Tension. In: Acta Neurochirurgica, Supplement. 1998 ; Vol. 1998, No. SUPPL. 71. pp. 166-169.
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