Determination of pulmonary blood flow by the rebreathing technique in airflow obstruction

M. E. Reinhart, J. R. Hughes, M. Kung, W. M. Abraham, T. Ahmed, P. Eyre, Adam Wanner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To test the hypothesis that the effect of nonuniform gas distribution on the uptake of inhaled soluble gases in the lung is minimized by rebreathing, we measured pulmonary blood flow by the thermodilution technique, and pulmonary capillary blood flow, combined pulmonary tissue and capillary blood volume, diffusing capacity of the lung for CO, and alveolar volume by a rebreathing technique in conscious sheep before and immediately after inhalation of a histamine aerosol (4% solution). We also measured pulmonary resistance, distribution of ventilation by multiplebreath N 2 washout, and arterial blood gases to monitor airway response. Histamine inhalation produced a mean pulmonary resistance increase to 621% of baseline accompanied by uneven distribution of ventilation and a decrease in arterial P(O 2). Despite these alterations in airway function, there were no concomitant changes in pulmonary capillary blood flow, combined pulmonary tissue and capillary blood volume, diffusing capacity of the lung for CO, alveolar volume, or the ratio of diffusing capacity for CO to alveolar volume. Mean pulmonary capillary blood flow and pulmonary blood flow did not differ from each other before and after histamine inhalation. We conclude that the rebreathing technique for noninvasive measurement of pulmonary hemodynamics is satisfactory in the presence of airflow obstruction.

Original languageEnglish
Pages (from-to)533-540
Number of pages8
JournalAmerican Review of Respiratory Disease
Volume120
Issue number3
StatePublished - Dec 1 1979
Externally publishedYes

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Lung
Carbon Monoxide
Histamine
Inhalation
Lung Volume Measurements
Gases
Blood Volume
Ventilation
Thermodilution
Aerosols
Sheep
Hemodynamics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Reinhart, M. E., Hughes, J. R., Kung, M., Abraham, W. M., Ahmed, T., Eyre, P., & Wanner, A. (1979). Determination of pulmonary blood flow by the rebreathing technique in airflow obstruction. American Review of Respiratory Disease, 120(3), 533-540.

Determination of pulmonary blood flow by the rebreathing technique in airflow obstruction. / Reinhart, M. E.; Hughes, J. R.; Kung, M.; Abraham, W. M.; Ahmed, T.; Eyre, P.; Wanner, Adam.

In: American Review of Respiratory Disease, Vol. 120, No. 3, 01.12.1979, p. 533-540.

Research output: Contribution to journalArticle

Reinhart, ME, Hughes, JR, Kung, M, Abraham, WM, Ahmed, T, Eyre, P & Wanner, A 1979, 'Determination of pulmonary blood flow by the rebreathing technique in airflow obstruction', American Review of Respiratory Disease, vol. 120, no. 3, pp. 533-540.
Reinhart ME, Hughes JR, Kung M, Abraham WM, Ahmed T, Eyre P et al. Determination of pulmonary blood flow by the rebreathing technique in airflow obstruction. American Review of Respiratory Disease. 1979 Dec 1;120(3):533-540.
Reinhart, M. E. ; Hughes, J. R. ; Kung, M. ; Abraham, W. M. ; Ahmed, T. ; Eyre, P. ; Wanner, Adam. / Determination of pulmonary blood flow by the rebreathing technique in airflow obstruction. In: American Review of Respiratory Disease. 1979 ; Vol. 120, No. 3. pp. 533-540.
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