Determination of cranio-spinal canal compliance distribution by MRI: Methodology and early application in idiopathic intracranial hypertension

Rong Wen Tain, Ahmet M. Bagci, Byron L. Lam, Evelyn M. Sklar, Birgit Ertl-Wagner, Noam Alperin

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Purpose: To develop a method for derivation of the cranial-spinal compliance distribution, assess its reliability, and apply to obese female patients with a diagnosis of idiopathic intracranial hypertension (IIH). Materials and Methods: Phase contrast-based measurements of blood and cerebrospinal fluid (CSF) flows to, from, and between the cranial and spinal canal compartments were used with lumped-parameter modeling to estimate systolic volume and pressure changes from which cranial and spinal compliance indices are obtained. The proposed MRI indices are analogous to pressure volume indices (PVI) currently being measured invasively with infusion-based techniques. The consistency of the proposed method was assessed using MRI data from seven aged healthy subjects. Measurement reproducibility was assessed using five repeated MR scans from one subject. The method was then applied to compare spinal canal compliance contribution in seven IIH patients and six matched healthy controls. Results: In the healthy subjects, as expected, spinal canal contribution was consistently larger than the cranial contribution (average value of 69%). Measurement variability was 8%. In IIH, the spinal canal contribution is significantly smaller than normal controls (60 versus 78%, P < 0.03). Conclusion: An MRI-based method for derivation of compliance indices analogous to PVI has been implemented and applied to healthy subjects. The application of the method to obese IIH patients suggests a spinal canal involvement in the pathophysiology of IIH.

Original languageEnglish (US)
Pages (from-to)1397-1404
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume34
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • cranio-spinal compliance
  • CSF and blood flows
  • intracranial pressure
  • lumped parameter modeling
  • phase contrast
  • spinal canal compliance

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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