Determinants of HIV-Specific CD8 T-cell responses in HIV-infected pediatric patients and enhancement of HIV-gag-specific responses with exogenous IL-15

Vivek Chitnis, Rajendra Pahwa, Savita G Pahwa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Cellular immune responses play a central role in controlling HIV-1 infection. HIV-specific IFN-γ production by CD8 T cells was evaluated in 17 HLA-A2+ HIV-infected pediatric patients (age range 1 month to 16 years) in an ELISPOT assay. Most patients (15/17) exhibited responses to HIV-gag, followed by responses to envelope gp120, gp41, and V3 loop. Only 7 patients responded to all four antigenic peptides. Treatment-related immune reconstitution of CD4 T cells was associated with increase in gag-specific responses, but these declined with prolonged viral suppression. Exogenous IL-15 resulted in augmentation of HIV-gag-specific response in 71% of patients, while IL-2 and IL-7 had variable effects, augmenting responses in 25% patients. Thus, HIV-specific CD8 T-cell responses are dependent on both CD4 T-cell help and antigenic stimulation. The cytokine IL-15 may be a useful modality as adjunctive therapy to augment HIV-specific memory CD8 T cells.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalClinical Immunology
Volume107
Issue number1
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Interleukin-15
HIV
Pediatrics
T-Lymphocytes
HLA-A2 Antigen
Enzyme-Linked Immunospot Assay
Interleukin-7
Cellular Immunity
HIV Infections
Interleukin-2
HIV-1
Cytokines
Peptides
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Determinants of HIV-Specific CD8 T-cell responses in HIV-infected pediatric patients and enhancement of HIV-gag-specific responses with exogenous IL-15. / Chitnis, Vivek; Pahwa, Rajendra; Pahwa, Savita G.

In: Clinical Immunology, Vol. 107, No. 1, 01.04.2003, p. 36-45.

Research output: Contribution to journalArticle

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