Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population

Ta Chang, Nathan G. Congdon, Robert Wojciechowski, Beatriz Muñoz, Donna Gilbert, Ping Chen, David S. Friedman, Sheila K. West

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.

Original languageEnglish
Pages (from-to)1186-1191
Number of pages6
JournalOphthalmology
Volume112
Issue number7
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

Fingerprint

Intraocular Pressure
Siblings
Population
Glaucoma
Confidence Intervals
Social Adjustment
Ocular Hypertension
Optic Nerve
Visual Fields
Linear Models
Arterial Pressure
Cohort Studies
Referral and Consultation
History
Steroids
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chang, T., Congdon, N. G., Wojciechowski, R., Muñoz, B., Gilbert, D., Chen, P., ... West, S. K. (2005). Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population. Ophthalmology, 112(7), 1186-1191. https://doi.org/10.1016/j.ophtha.2005.03.006

Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population. / Chang, Ta; Congdon, Nathan G.; Wojciechowski, Robert; Muñoz, Beatriz; Gilbert, Donna; Chen, Ping; Friedman, David S.; West, Sheila K.

In: Ophthalmology, Vol. 112, No. 7, 01.07.2005, p. 1186-1191.

Research output: Contribution to journalArticle

Chang, T, Congdon, NG, Wojciechowski, R, Muñoz, B, Gilbert, D, Chen, P, Friedman, DS & West, SK 2005, 'Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population', Ophthalmology, vol. 112, no. 7, pp. 1186-1191. https://doi.org/10.1016/j.ophtha.2005.03.006
Chang, Ta ; Congdon, Nathan G. ; Wojciechowski, Robert ; Muñoz, Beatriz ; Gilbert, Donna ; Chen, Ping ; Friedman, David S. ; West, Sheila K. / Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population. In: Ophthalmology. 2005 ; Vol. 112, No. 7. pp. 1186-1191.
@article{d8d45d6363904c77b42a237415e4050e,
title = "Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population",
abstract = "Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95{\%} confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95{\%} CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19{\%}) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.",
author = "Ta Chang and Congdon, {Nathan G.} and Robert Wojciechowski and Beatriz Mu{\~n}oz and Donna Gilbert and Ping Chen and Friedman, {David S.} and West, {Sheila K.}",
year = "2005",
month = "7",
day = "1",
doi = "10.1016/j.ophtha.2005.03.006",
language = "English",
volume = "112",
pages = "1186--1191",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population

AU - Chang, Ta

AU - Congdon, Nathan G.

AU - Wojciechowski, Robert

AU - Muñoz, Beatriz

AU - Gilbert, Donna

AU - Chen, Ping

AU - Friedman, David S.

AU - West, Sheila K.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.

AB - Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.

UR - http://www.scopus.com/inward/record.url?scp=21444460561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21444460561&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2005.03.006

DO - 10.1016/j.ophtha.2005.03.006

M3 - Article

C2 - 15939473

AN - SCOPUS:21444460561

VL - 112

SP - 1186

EP - 1191

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 7

ER -