Abstract
Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.
| Original language | English |
|---|---|
| Pages (from-to) | 1186-1191 |
| Number of pages | 6 |
| Journal | Ophthalmology |
| Volume | 112 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2005 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
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Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population. / Chang, Ta; Congdon, Nathan G.; Wojciechowski, Robert; Muñoz, Beatriz; Gilbert, Donna; Chen, Ping; Friedman, David S.; West, Sheila K.
In: Ophthalmology, Vol. 112, No. 7, 01.07.2005, p. 1186-1191.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determinants and heritability of intraocular pressure and cup-to-disc ratio in a defined older population
AU - Chang, Ta
AU - Congdon, Nathan G.
AU - Wojciechowski, Robert
AU - Muñoz, Beatriz
AU - Gilbert, Donna
AU - Chen, Ping
AU - Friedman, David S.
AU - West, Sheila K.
PY - 2005/7/1
Y1 - 2005/7/1
N2 - Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.
AB - Purpose: To investigate the heritability of intraocular pressure (IOP) and cup-to-disc ratio (CDR) in an older well-defined population. Design: Family-based cohort study. Participants: Through the population-based Salisbury Eye Evaluation study, we recruited 726 siblings (mean age, 74.7 years) in 284 sibships. Methods: Intraocular pressure and CDR were measured bilaterally for all participants. The presence or absence of glaucoma was determined by a glacuoma specialist for all probands on the basis of visual field, optic nerve appearance, and history. The heritability of IOP was calculated as twice the residual between-sibling correlation of IOP using linear regression and generalized estimating equations after adjusting for age, gender, mean arterial pressure, race, self-reported diabetes status, and history of systemic steroid use. The heritability of CDR was calculated using the same model and adjustments as above, while also adjusting for IOP. Main Outcome Measures: Heritability and determinants of IOP and CDR, and impact of siblings' glaucoma status on IOP and CDR. Results: We estimated the heritability to be 0.29 (95% confidence interval [CI], 0.12-0.46) for IOP and 0.56 (95% CI, 0.35-0.76) for CDR in this population. Mean IOP in siblings of glaucomatous probands was statistically significantly higher than in siblings of normal probands (mean difference, 1.02 mmHg; P = 0.017). The mean CDR in siblings of glaucomatous probands was 0.07 (or 19%) larger than in siblings of glaucoma suspect referrals (P = 0.045) and siblings of normal probands (P = 0.004). Conclusions: In this elderly population, we found CDR to be highly heritable and IOP to be moderately heritable. On average, siblings of glaucoma patients had higher IOPs and larger CDRs than siblings of nonglaucomatous probands.
UR - http://www.scopus.com/inward/record.url?scp=21444460561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21444460561&partnerID=8YFLogxK
U2 - 10.1016/j.ophtha.2005.03.006
DO - 10.1016/j.ophtha.2005.03.006
M3 - Article
C2 - 15939473
AN - SCOPUS:21444460561
VL - 112
SP - 1186
EP - 1191
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 7
ER -