Detection of ultra-early brain damage after acute subdural hematoma in the rat by magnetic resonance imaging

Eiji Tsuchida, Beat Alessandri, Frank Corwin, Panos Fatouros, Ross Bullock

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We measured serial changes in diffusion-weighted magnetic resonance imaging (DW) and in apparent diffusion coefficient (ADC) 1 to 3 hours after induction of acute subdural hematoma (ASDH) in rats, to assess the rate of development of cytotoxic edema and ischemic brain damage observed in this model. Cortical ADC values underneath the hematoma in ASDH rats (n = 12) were significantly lower than those in sham-operated rats (n = 5) at 1 hour. By 3 hours, the area of ADC abnormality had further increased. The lesion areas, as percentage of hemispheric areas on 1- and 3-hour ADC maps, correlated significantly with those on the histologic sections stained with hematoxylin and eosin. The results indicate that DWI with ADC mapping may provide a valuable diagnostic tool for monitoring of early pathologic changes following subdural hematoma in head-injured patients.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalJournal of neurotrauma
Volume16
Issue number7
DOIs
StatePublished - Jul 1999

Keywords

  • Acute subdural hematoma
  • Apparent diffusion coefficient
  • Diffusion- weighted images
  • Magnetic resonance imaging
  • Rat

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Detection of ultra-early brain damage after acute subdural hematoma in the rat by magnetic resonance imaging'. Together they form a unique fingerprint.

  • Cite this