Abstract
The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
Original language | English (US) |
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Pages (from-to) | 1253-1259 |
Number of pages | 7 |
Journal | European Journal of Immunology |
Volume | 19 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology