Abstract
The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 1253-1259 |
| Number of pages | 7 |
| Journal | European Journal of Immunology |
| Volume | 19 |
| Issue number | 7 |
| State | Published - Jan 1 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus. / Muller, C.; Kagi, D.; Aebischer, T.; Odermatt, B.; Held, W.; Podack, E. R.; Zinkernagel, R. M.; Hengartner, H.
In: European Journal of Immunology, Vol. 19, No. 7, 01.01.1989, p. 1253-1259.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus
AU - Muller, C.
AU - Kagi, D.
AU - Aebischer, T.
AU - Odermatt, B.
AU - Held, W.
AU - Podack, E. R.
AU - Zinkernagel, R. M.
AU - Hengartner, H.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
AB - The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
UR - http://www.scopus.com/inward/record.url?scp=0024379645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024379645&partnerID=8YFLogxK
M3 - Article
VL - 19
SP - 1253
EP - 1259
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 7
ER -