Abstract
The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1253-1259 |
| Number of pages | 7 |
| Journal | European Journal of Immunology |
| Volume | 19 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1989 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Cite this
Müller, C., Kägi, D., Aebischer, T., Odermatt, B., Held, W., Podack, E. R., Zinkernagel, R. M., & Hengartner, H. (1989). Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus. European Journal of Immunology, 19(7), 1253-1259. https://doi.org/10.1002/eji.1830190716