Detection of low avidity anti‐dna antibodies in systemic lupus erythematosus

Richard L. Riley, Hugh Mcgrath, Ronald P. Taylor

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalArthritis & Rheumatism
Volume22
Issue number3
DOIs
StatePublished - Mar 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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