Detection of low avidity anti‐dna antibodies in systemic lupus erythematosus

Richard L. Riley; Hugh Mcgrath; Ronald P. Taylor

doi:10.1002/art.1780220303

Detection of low avidity anti‐dna antibodies in systemic lupus erythematosus

Richard L. Riley, Hugh Mcgrath, Ronald P. Taylor

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.

Original language	English (US)
Pages (from-to)	219-225
Number of pages	7
Journal	Arthritis & Rheumatism
Volume	22
Issue number	3
DOIs	https://doi.org/10.1002/art.1780220303
State	Published - Mar 1979
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.",

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