Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus

Richard L Riley, H. McGrath, R. P. Taylor

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalArthritis and Rheumatism
Volume22
Issue number3
StatePublished - Jan 1 1979
Externally publishedYes

Fingerprint

Antinuclear Antibodies
Systemic Lupus Erythematosus
Antibody Affinity
Serum
Antibodies
DNA

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus. / Riley, Richard L; McGrath, H.; Taylor, R. P.

In: Arthritis and Rheumatism, Vol. 22, No. 3, 01.01.1979, p. 219-225.

Research output: Contribution to journalArticle

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