Detection of low avidity anti-DNA antibodies in systemic lupus erythematosus

Richard L Riley, H. McGrath, R. P. Taylor

Research output: Contribution to journalArticle

35 Scopus citations


The binding of sonicated, radiolabeled DNA by systemic lupus erythematosus (SLE) sera was measured by a high sensitivity polyethylene glycol (PEG) precipitation assay. This method is considerably more sensitive than currently used techniques. The results suggest that a significant concentration of low avidity antibodies is present in SLE sera; however, these antibodies are not detected by conventional techniques.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalArthritis and Rheumatism
Issue number3
StatePublished - Jan 1 1979
Externally publishedYes


ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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