Detection of intrahepatic human islets following combined liver-islet allotransplantation

Camillo Ricordi, A. Tzakis, Rodolfo Alejandro, Y. Zeng, A. J. Demetris, P. Carroll, J. J. Fung, D. H. Mintz, T. E. Starzl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This article describes the localization of intact insulin-containing intrahepatic islets after combined liver-islet allotransplantation. The patient was a 36-year-old woman who underwent upper abdominal exenteration for neuroendocrine carcinoma; 289,000 islets were transplanted via portal vein infusion immediately after complete revascularization of the liver. Immunosuppression was with low-dose FK-506. OKT3 and steroids were used to treat one rejection episode 2 weeks after transplantation, but the patient subsequently developed multiple infections and died 109 days after transplantation. At autopsy, the transplanted liver did not show any sign of rejection and well-preserved islets were present in portal triads sampled from the anterior inferior edge of the right lobe. Immunohistochemical labeling confirmed the presence of insulin-containing cells. This finding indicated that human islets can survive after intrahepatic allotransplantation, despite positive cross-match with no HLA antigen match, suggesting that upper abdominal exenteration and liver transplantation may constitute a protective factor for the survival of allogeneic human islets.

Original languageEnglish
Pages (from-to)507-509
Number of pages3
JournalPancreas
Volume7
Issue number4
StatePublished - Jul 13 1992

Fingerprint

Liver
Transplantation
Insulin
Neuroendocrine Carcinoma
Muromonab-CD3
Tacrolimus
HLA Antigens
Portal Vein
Liver Transplantation
Immunosuppression
Autopsy
Steroids
Survival
Infection
Protective Factors

Keywords

  • Human
  • Islet
  • Transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Endocrinology

Cite this

Ricordi, C., Tzakis, A., Alejandro, R., Zeng, Y., Demetris, A. J., Carroll, P., ... Starzl, T. E. (1992). Detection of intrahepatic human islets following combined liver-islet allotransplantation. Pancreas, 7(4), 507-509.

Detection of intrahepatic human islets following combined liver-islet allotransplantation. / Ricordi, Camillo; Tzakis, A.; Alejandro, Rodolfo; Zeng, Y.; Demetris, A. J.; Carroll, P.; Fung, J. J.; Mintz, D. H.; Starzl, T. E.

In: Pancreas, Vol. 7, No. 4, 13.07.1992, p. 507-509.

Research output: Contribution to journalArticle

Ricordi, C, Tzakis, A, Alejandro, R, Zeng, Y, Demetris, AJ, Carroll, P, Fung, JJ, Mintz, DH & Starzl, TE 1992, 'Detection of intrahepatic human islets following combined liver-islet allotransplantation', Pancreas, vol. 7, no. 4, pp. 507-509.
Ricordi, Camillo ; Tzakis, A. ; Alejandro, Rodolfo ; Zeng, Y. ; Demetris, A. J. ; Carroll, P. ; Fung, J. J. ; Mintz, D. H. ; Starzl, T. E. / Detection of intrahepatic human islets following combined liver-islet allotransplantation. In: Pancreas. 1992 ; Vol. 7, No. 4. pp. 507-509.
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