Detection of human T-cell leukemia/lymphoma virus type I in a transfusion recipient with chronic myelopathy

E. H. Saxton, H. Lee, P. Swanson, I. S.Y. Chen, C. Ruland, E. Chin, D. Aboulafia, R. Delamarter, J. D. Rosenblatt

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A white man with a progressive spastic paraparesis that began 15 months after sustaining severe trauma in a motor vehicle accident was positive for antibodies to human T-lymphotropic virus type (HTLV-I) by enzyme-linked immunosorbent assay. Serum antibody to HTLV-I was confirmed by Western blot and radioimmunoprecipitation assay. We detected specific proviral DNA in peripheral blood lymphocytes by the polymerase chain reaction. Because the incidence of HTLV-I is generally restricted to Southern Japan and Caribbean black populations, the most likely source of HTLV-I infection in this patient was multiple intraoperative blood transfusions. The relatively short interval between transfusion and development of HTLV-I-associated myelopathy is consistent with the more rapid evolution of this clinical syndrome compared with adult T-cell leukemia.

Original languageEnglish (US)
Pages (from-to)841-844
Number of pages4
JournalNeurology
Volume39
Issue number6
DOIs
StatePublished - Jun 1989
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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