Detection of gliotoxin in experimental and human aspergillosis

Russell E. Lewis, Nathan P. Wiederhold, Jingduan Chi, Xiang Y. Han, Krishna V. Komanduri, Dimitrios P. Kontoyiannis, Randall A. Prince

Research output: Contribution to journalArticle

122 Scopus citations

Abstract

Gliotoxin was measured in the lungs (mean, 3,976 ± 1,662 ng/g of tissue) and sera (mean, 36.5 ± 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalInfection and Immunity
Volume73
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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  • Cite this

    Lewis, R. E., Wiederhold, N. P., Chi, J., Han, X. Y., Komanduri, K. V., Kontoyiannis, D. P., & Prince, R. A. (2005). Detection of gliotoxin in experimental and human aspergillosis. Infection and Immunity, 73(1), 635-637. https://doi.org/10.1128/IAI.73.1.635-637.2005