Detection of colorectal liver metastases: A prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT

Carlo Bartolozzi, Francescamaria Donati, Dania Cioni, Carlo Procacci, Giovanni Morana, Antonio Chiesa, Luigi Grazioli, Giorgio Cittadini, Giuseppe Cittadini, Andrea Giovagnoni, Giovanni Gandini, Jochen Maass, Riccardo Lencioni

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99 Scopus citations

Abstract

The aim of this study was to compare unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT in the detection of hepatic colorectal metastases. Forty-four patients with hepatic colorectal metastases were examined with unenhanced and MnDPDP-enhanced MRI and with unenhanced and contrast-enhanced spiral CT. The MR examination protocol included baseline T1-weighted spin-echo (SE), T1-weighted gradient-recalled-echo (GRE), and T2-weighted fast-SE sequences; and T1-weighted SE and T1-weighted GRE sequences obtained 30-60 min after administration of 0.5 μmol/kg (0.5 ml/kg) mangafodipir trisodium (MnDPDP). Images were interpreted by three blinded readers. Findings at CT and MRI were compared with those at intraoperative US, which were used as term of reference. Intraoperative US detected 128 metastases. In a lesion-by-lesion analysis, the overall detection rate was 71% (91 of 128) for spiral CT, 72% (92 of 128) for unenhanced MRI, and 90% (115 of 128) for MnDPDP-enhanced MRI. MnDPDP-enhanced MRI was more sensitive than either unenhanced MRI (p<0.0001) or spiral CT (p=0.0007). In a patient-by-patient analysis, agreement with gold standard was higher for MnDPDP-enhanced MRI (33 of 44 cases) than for spiral CT (22 of 44 cases, p=0.0023) and unenhanced MRI (21 of 44 cases, p=0.0013). MnDPDP-enhanced MRI is superior to unenhanced MRI and spiral CT in the detection of hepatic colorectal metastases.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalEuropean Radiology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Computed tomography
  • Contrast media
  • Liver neoplasms
  • Magnetic resonance
  • Mangafodipir trisodium
  • Metastases

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Bartolozzi, C., Donati, F., Cioni, D., Procacci, C., Morana, G., Chiesa, A., Grazioli, L., Cittadini, G., Cittadini, G., Giovagnoni, A., Gandini, G., Maass, J., & Lencioni, R. (2004). Detection of colorectal liver metastases: A prospective multicenter trial comparing unenhanced MRI, MnDPDP-enhanced MRI, and spiral CT. European Radiology, 14(1), 14-20. https://doi.org/10.1007/s00330-003-1966-9