Detection of cerebral emboli signals in patients with carotid stenosis and cardiac disease

Vida Demarin, Tanja Rundek, Slava Podobnik-Šarkanji, Arijana Huzjan, Dražen Runjić

Research output: Contribution to journalArticlepeer-review


Background and purpose: Transcranial Doppler (TCD) has been recently used for detection of cerebral emboli in patients with cardiac and carotid diseases, although clinical relevance of emboli detection is still unknown. Therefore, in order to analyze the prevalence of cerebral emboli we analyzed 70 stroke patients with carotid or cardiac origin of stroke. Material and methods: Out of 70 analyzed stroke patents, 35 patients had extracranial carotid artery disease (11 stenosis>80% and 24 stenosis<79%) and 35 patients had atrial fibrillation (AF). The simultaneous 30-minutes TCD monitoring of both middle cerebral arteries (MCA) was performed by Multi-Dop X (DWL). Emboli signals were categorized according to the intensity of the Doppler amplitude into 6 groups: 3,6,9,12,15, and >18 dB. Results: All patients had detectable signals of amplitude 3 and 6 dB, and 32 patients (91%) had emboli signals higher than 12 dB. The average distribution of emboli signals in patients with AF was: 7, 21, 43, 12, 3, 0/ 30 min, with carotid stenosis>80%: 3, 21, 19, 13, 11, 4/ 30 min, and with stenosis<79%: 1, 2, 3, 2, 2, 1/ 30 min (p<0.01). Statistically significant difference of the emboli prevalence was not found between the left and the right MCA. Patients with AF and patients with the carotid stenosis>80% had the higher prevalence of emboli signals of the amphtude>12 dB (56 signals/30 min, 49 signals/30 min) than patients with the carotid stenosis<79% (24 signals/30 min), p<0.01. Conclusions: The TCD-cerebral emboli recording method has a clinical impact in detection of potentially subclinical embolization, and shortly in the future it will be widely used in clinical decision-making process for therapy, prognosis and prevention of stroke.

Original languageEnglish (US)
Pages (from-to)83-88
Number of pages6
JournalPeriodicum Biologorum
Issue number1
StatePublished - Mar 1 1996
Externally publishedYes


  • Atrial fibrillation
  • Carotid stenosis
  • Cerebral emboli
  • Transcranial Doppler

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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