Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma

S. Bekri, J. Adélaide, S. Merscher, J. Grosgeorge, F. Caroli-Bosc, D. Perucca-Lostanlen, P. M. Kelley, M. J. Pébusque, C. Theillet, D. Birnbaum, P. Gaudray

Research output: Contribution to journalArticlepeer-review

127 Scopus citations

Abstract

Amplification of loci present on band q13 of human chromosome 11 is a feature of a subset of estrogen receptor positive breast carcinomas prone to metastasis. As many as five distinct amplification units have been described on 11q13. They include particularly a genomic area encompassing the GARP gene at 11q13.5→q14.1. We have reassessed our current knowledge of this region, located telomeric to CCND1 and EMS1, which is amplified in 7-10% of mammary tumors. The loose definition of the driving forces of these amplification events led us to map accurately the boundaries of the amplifiable region, and thus to contribute a physical and transcriptional map of a 3-Mb region of chromosome 11. Four new genes were placed on the regional map, namely CBP2, CLNS1A, UVRAG, and PAK1. We have narrowed the core of the llq13→q14 amplicon to a 350-kb area encompassing D11S533, mostly on its telomeric side. The map reported here represents an indispensable step toward sequencing the entire region, and thus toward uncovering gene(s) which play(s) a critical role in breast cancer progression.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalCytogenetic and Genome Research
Volume79
Issue number1-2
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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