Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease

Alzheimer’s Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND: Accumulating evidence shows that gradual loss of white matter integrity plays an important role in the development of Alzheimer disease (AD).

OBJECTIVE: The aim of this research was to study the microstructural integrity of white matter in AD in vivo.

METHODS: Global fractional anisotropy, global axial diffusivity (AxD), and global radial diffusivity (RD) were analyzed in subjects with normal controls (NC), mild cognitive impairment (MCI), and AD using Alzheimer's Disease Neuroimaging Initiative data (total N = 210). We further compared specific white matter tracts among the 3 groups.

RESULTS: Compared with the NC group, the MCI group had significantly increased global AxD and global RD. Compared with the NC and MCI groups, the AD group had significantly decreased global fractional anisotropy, increased global AxD, and increased global RD. With regard to specific white matter tracts, in the MCI group, we found increased AxD and increased RD in the external capsule, part of the lateral cholinergic pathway, in addition to the tracts connecting the limbic regions, predominantly in the left hemisphere. In the AD group, white matter abnormalities were widespread, including in the external capsule (cholinergic pathway) and limbic region tracts as well as tracts connecting anterior to posterior regions bilaterally.

CONCLUSIONS: The radiographic manifestation of damaged white matter microstructural integrity in the cholinergic pathway in MCI patients may provide a rational basis for the use of cholinesterase inhibitor drugs in the MCI stage of AD.

Original languageEnglish (US)
Pages (from-to)927-933
Number of pages7
JournalJournal of investigative medicine : the official publication of the American Federation for Clinical Research
Volume62
Issue number7
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

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Alzheimer Disease
Cholinergic Agents
Anisotropy
Capsules
Neuroimaging
Cholinesterase Inhibitors
Cognitive Dysfunction
White Matter
Control Groups
Research
Pharmaceutical Preparations
External Capsule

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease. / Alzheimer’s Disease Neuroimaging Initiative.

In: Journal of investigative medicine : the official publication of the American Federation for Clinical Research, Vol. 62, No. 7, 01.10.2014, p. 927-933.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND: Accumulating evidence shows that gradual loss of white matter integrity plays an important role in the development of Alzheimer disease (AD).OBJECTIVE: The aim of this research was to study the microstructural integrity of white matter in AD in vivo.METHODS: Global fractional anisotropy, global axial diffusivity (AxD), and global radial diffusivity (RD) were analyzed in subjects with normal controls (NC), mild cognitive impairment (MCI), and AD using Alzheimer's Disease Neuroimaging Initiative data (total N = 210). We further compared specific white matter tracts among the 3 groups.RESULTS: Compared with the NC group, the MCI group had significantly increased global AxD and global RD. Compared with the NC and MCI groups, the AD group had significantly decreased global fractional anisotropy, increased global AxD, and increased global RD. With regard to specific white matter tracts, in the MCI group, we found increased AxD and increased RD in the external capsule, part of the lateral cholinergic pathway, in addition to the tracts connecting the limbic regions, predominantly in the left hemisphere. In the AD group, white matter abnormalities were widespread, including in the external capsule (cholinergic pathway) and limbic region tracts as well as tracts connecting anterior to posterior regions bilaterally.CONCLUSIONS: The radiographic manifestation of damaged white matter microstructural integrity in the cholinergic pathway in MCI patients may provide a rational basis for the use of cholinesterase inhibitor drugs in the MCI stage of AD.",
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