Desmoid tumor

Analysis of prognostic factors and outcomes in a surgical series

John T. Mullen, Thomas F. DeLaney, Wendy K. Kobayashi, Jackie Szymonifka, Beow Y. Yeap, Yen Lin Chen, Andrew Rosenberg, David C. Harmon, Edwin Choy, Sam S. Yoon, Kevin A. Raskin, G. Petur Nielsen, Francis J. Hornicek

Research output: Contribution to journalArticle

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Abstract

Background. Desmoid tumors are rare and exhibit a highly unpredictable natural history. We sought to analyze prognostic factors associated with recurrence in a large single-institution study of patients with desmoid tumors. Methods. We performed a retrospective review of 177 patients with desmoid tumor who underwent macroscopi-cally complete surgical resection, with or without the addition of radiotherapy (RT) or systemic therapy, from 1970 to 2009. We examined patterns of presentation, all known risk factors for recurrence, and their association with recurrence-free survival (RFS). Results. Twenty-two patients (12 %) had intra-abdominal desmoid tumors, and 155 (88 %) had extra-abdominal tumors. Patterns of presentation included primary (n = 133, 75 %) and locally recurrent (n = 44, 25 %) disease. Treatment was surgery alone in 125 patients (71 %), surgery and RT in 36 (20 %), and surgery and systemic therapy with or without RT in 20 (11 %). Median follow-up was 40 months. Overall, the local relapse rate was 29 %, and 10-year RFS was 60 %. R0 resection status was the only predictor of freedom from local recurrence on multivariate analysis (odds ratio 0.32; 95 % confidence interval 0.15-0.66; P = 0.002). The selective use of adjuvant RT appeared to improve local control in patients with positive margins. Conclusions. For patients with desmoid tumors undergoing surgery, wide excision with negative margins should be the goal, but not at the expense of function, as fewer than half of patients with positive margins will experience recurrence.

Original languageEnglish
Pages (from-to)4028-4035
Number of pages8
JournalAnnals of Surgical Oncology
Volume19
Issue number13
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

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Aggressive Fibromatosis
Recurrence
Neoplasms
Radiotherapy
Adjuvant Radiotherapy
Survival
Natural History
Therapeutics
Multivariate Analysis
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Mullen, J. T., DeLaney, T. F., Kobayashi, W. K., Szymonifka, J., Yeap, B. Y., Chen, Y. L., ... Hornicek, F. J. (2012). Desmoid tumor: Analysis of prognostic factors and outcomes in a surgical series. Annals of Surgical Oncology, 19(13), 4028-4035. https://doi.org/10.1245/s10434-012-2638-2

Desmoid tumor : Analysis of prognostic factors and outcomes in a surgical series. / Mullen, John T.; DeLaney, Thomas F.; Kobayashi, Wendy K.; Szymonifka, Jackie; Yeap, Beow Y.; Chen, Yen Lin; Rosenberg, Andrew; Harmon, David C.; Choy, Edwin; Yoon, Sam S.; Raskin, Kevin A.; Nielsen, G. Petur; Hornicek, Francis J.

In: Annals of Surgical Oncology, Vol. 19, No. 13, 01.12.2012, p. 4028-4035.

Research output: Contribution to journalArticle

Mullen, JT, DeLaney, TF, Kobayashi, WK, Szymonifka, J, Yeap, BY, Chen, YL, Rosenberg, A, Harmon, DC, Choy, E, Yoon, SS, Raskin, KA, Nielsen, GP & Hornicek, FJ 2012, 'Desmoid tumor: Analysis of prognostic factors and outcomes in a surgical series', Annals of Surgical Oncology, vol. 19, no. 13, pp. 4028-4035. https://doi.org/10.1245/s10434-012-2638-2
Mullen JT, DeLaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL et al. Desmoid tumor: Analysis of prognostic factors and outcomes in a surgical series. Annals of Surgical Oncology. 2012 Dec 1;19(13):4028-4035. https://doi.org/10.1245/s10434-012-2638-2
Mullen, John T. ; DeLaney, Thomas F. ; Kobayashi, Wendy K. ; Szymonifka, Jackie ; Yeap, Beow Y. ; Chen, Yen Lin ; Rosenberg, Andrew ; Harmon, David C. ; Choy, Edwin ; Yoon, Sam S. ; Raskin, Kevin A. ; Nielsen, G. Petur ; Hornicek, Francis J. / Desmoid tumor : Analysis of prognostic factors and outcomes in a surgical series. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 13. pp. 4028-4035.
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abstract = "Background. Desmoid tumors are rare and exhibit a highly unpredictable natural history. We sought to analyze prognostic factors associated with recurrence in a large single-institution study of patients with desmoid tumors. Methods. We performed a retrospective review of 177 patients with desmoid tumor who underwent macroscopi-cally complete surgical resection, with or without the addition of radiotherapy (RT) or systemic therapy, from 1970 to 2009. We examined patterns of presentation, all known risk factors for recurrence, and their association with recurrence-free survival (RFS). Results. Twenty-two patients (12 {\%}) had intra-abdominal desmoid tumors, and 155 (88 {\%}) had extra-abdominal tumors. Patterns of presentation included primary (n = 133, 75 {\%}) and locally recurrent (n = 44, 25 {\%}) disease. Treatment was surgery alone in 125 patients (71 {\%}), surgery and RT in 36 (20 {\%}), and surgery and systemic therapy with or without RT in 20 (11 {\%}). Median follow-up was 40 months. Overall, the local relapse rate was 29 {\%}, and 10-year RFS was 60 {\%}. R0 resection status was the only predictor of freedom from local recurrence on multivariate analysis (odds ratio 0.32; 95 {\%} confidence interval 0.15-0.66; P = 0.002). The selective use of adjuvant RT appeared to improve local control in patients with positive margins. Conclusions. For patients with desmoid tumors undergoing surgery, wide excision with negative margins should be the goal, but not at the expense of function, as fewer than half of patients with positive margins will experience recurrence.",
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T2 - Analysis of prognostic factors and outcomes in a surgical series

AU - Mullen, John T.

AU - DeLaney, Thomas F.

AU - Kobayashi, Wendy K.

AU - Szymonifka, Jackie

AU - Yeap, Beow Y.

AU - Chen, Yen Lin

AU - Rosenberg, Andrew

AU - Harmon, David C.

AU - Choy, Edwin

AU - Yoon, Sam S.

AU - Raskin, Kevin A.

AU - Nielsen, G. Petur

AU - Hornicek, Francis J.

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N2 - Background. Desmoid tumors are rare and exhibit a highly unpredictable natural history. We sought to analyze prognostic factors associated with recurrence in a large single-institution study of patients with desmoid tumors. Methods. We performed a retrospective review of 177 patients with desmoid tumor who underwent macroscopi-cally complete surgical resection, with or without the addition of radiotherapy (RT) or systemic therapy, from 1970 to 2009. We examined patterns of presentation, all known risk factors for recurrence, and their association with recurrence-free survival (RFS). Results. Twenty-two patients (12 %) had intra-abdominal desmoid tumors, and 155 (88 %) had extra-abdominal tumors. Patterns of presentation included primary (n = 133, 75 %) and locally recurrent (n = 44, 25 %) disease. Treatment was surgery alone in 125 patients (71 %), surgery and RT in 36 (20 %), and surgery and systemic therapy with or without RT in 20 (11 %). Median follow-up was 40 months. Overall, the local relapse rate was 29 %, and 10-year RFS was 60 %. R0 resection status was the only predictor of freedom from local recurrence on multivariate analysis (odds ratio 0.32; 95 % confidence interval 0.15-0.66; P = 0.002). The selective use of adjuvant RT appeared to improve local control in patients with positive margins. Conclusions. For patients with desmoid tumors undergoing surgery, wide excision with negative margins should be the goal, but not at the expense of function, as fewer than half of patients with positive margins will experience recurrence.

AB - Background. Desmoid tumors are rare and exhibit a highly unpredictable natural history. We sought to analyze prognostic factors associated with recurrence in a large single-institution study of patients with desmoid tumors. Methods. We performed a retrospective review of 177 patients with desmoid tumor who underwent macroscopi-cally complete surgical resection, with or without the addition of radiotherapy (RT) or systemic therapy, from 1970 to 2009. We examined patterns of presentation, all known risk factors for recurrence, and their association with recurrence-free survival (RFS). Results. Twenty-two patients (12 %) had intra-abdominal desmoid tumors, and 155 (88 %) had extra-abdominal tumors. Patterns of presentation included primary (n = 133, 75 %) and locally recurrent (n = 44, 25 %) disease. Treatment was surgery alone in 125 patients (71 %), surgery and RT in 36 (20 %), and surgery and systemic therapy with or without RT in 20 (11 %). Median follow-up was 40 months. Overall, the local relapse rate was 29 %, and 10-year RFS was 60 %. R0 resection status was the only predictor of freedom from local recurrence on multivariate analysis (odds ratio 0.32; 95 % confidence interval 0.15-0.66; P = 0.002). The selective use of adjuvant RT appeared to improve local control in patients with positive margins. Conclusions. For patients with desmoid tumors undergoing surgery, wide excision with negative margins should be the goal, but not at the expense of function, as fewer than half of patients with positive margins will experience recurrence.

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