Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics

Sachin Gupta, James M. Termini, Saravana Kanagavelu, Geoffrey W. Stone

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

TNF superfamily ligands play a critical role in the regulation of adaptive immune responses, including the costimulation of dendritic cells, T cells, and B cells. This costimulation could potentially be exploited for the development of prophylactic vaccines and immunotherapy. Despite this, there have been only a limited number of reports on the use of this family of molecules as gene-based adjuvants to enhance DNA and/or viral vector vaccines. In addition, the molecule latent membrane protein 1 (LMP1), a viral mimic of the TNF superfamily receptor CD40, provides an alternative approach for the design of novel molecular adjuvants. Here, we discuss advances in the development of recombinant TNF superfamily ligands as adjuvants for HIV vaccines and as cancer immunotherapy, including the use of LMP1 and LMP1-CD40 chimeric fusion proteins to mimic constitutive CD40 signaling.

Original languageEnglish (US)
Pages (from-to)303-310
Number of pages8
JournalImmunologic Research
Volume57
Issue number1-3
DOIs
StatePublished - Dec 2013

Keywords

  • 4-1BBL
  • APRIL
  • BAFF
  • CD40L
  • LMP1
  • OX40L
  • TNF Superfamily

ASJC Scopus subject areas

  • Immunology

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