Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern - Synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives

Ling He, He Xi Chang, Ting Chao Chou, Niramol Savaraj, C. C. Cheng

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyelocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume38
Issue number1
DOIs
StatePublished - Mar 1 2003

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Keywords

  • 11H-Indolo[3.2-c]quinoline derivatives
  • 2-Phenylnaphthalene-type
  • Antitumor activity

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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