Design of a family study among high-risk Caribbean Hispanics

the Northern Manhattan family study

Ralph L Sacco, Edison A. Sabala, Tatjana Rundek, Suh Hang Hank Juo, Jinaping Sam Huang, Marco DiTullio, Shunichi Homma, Katihurka Almonte, Carlos García Lithgow, Bernadette Boden-Albala

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Stroke continues to kill disproportionately more Blacks and Hispanics than Whites in the United States. Racial/ethnic variations in the incidence of stroke and prevalence of stroke risk factors are probably explained by both genetic and environmental influences. Family studies can help identify genetic predisposition to stroke and potential stroke precursors. Few studies have evaluated the heritability of these stroke risk factors among non-White populations, and none have focused on Caribbean Hispanic populations. The aim of the Northern Manhattan Family Study (NOMAFS) is to investigate the gene-environment interaction of stroke risk factors among Caribbean Hispanics. The unique recruitment and methodologic approaches used in this study are relevant to the design and conduct of genetic aggregation studies to investigate complex genetic disorders in non-White populations. The aim of this paper is to describe the NOMAFS and report enrollment and characteristics of the participants. The NOMAFS will provide a data resource for the exploration of the genetic determinants of highly heritable stroke precursor phenotypes that are less complex than the stroke phenotype. Understanding the gene environment interaction is the critical next step toward the development of new and unique approaches to disease prevention and interventions.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalEthnicity and Disease
Volume17
Issue number2
StatePublished - Mar 1 2007
Externally publishedYes

Fingerprint

Hispanic Americans
Stroke
Gene-Environment Interaction
Population
Phenotype
Inborn Genetic Diseases
Genetic Predisposition to Disease
Incidence

Keywords

  • Genetics
  • Hispanic
  • Stroke

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Sacco, R. L., Sabala, E. A., Rundek, T., Juo, S. H. H., Huang, J. S., DiTullio, M., ... Boden-Albala, B. (2007). Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan family study. Ethnicity and Disease, 17(2), 351-357.

Design of a family study among high-risk Caribbean Hispanics : the Northern Manhattan family study. / Sacco, Ralph L; Sabala, Edison A.; Rundek, Tatjana; Juo, Suh Hang Hank; Huang, Jinaping Sam; DiTullio, Marco; Homma, Shunichi; Almonte, Katihurka; Lithgow, Carlos García; Boden-Albala, Bernadette.

In: Ethnicity and Disease, Vol. 17, No. 2, 01.03.2007, p. 351-357.

Research output: Contribution to journalArticle

Sacco, RL, Sabala, EA, Rundek, T, Juo, SHH, Huang, JS, DiTullio, M, Homma, S, Almonte, K, Lithgow, CG & Boden-Albala, B 2007, 'Design of a family study among high-risk Caribbean Hispanics: the Northern Manhattan family study', Ethnicity and Disease, vol. 17, no. 2, pp. 351-357.
Sacco, Ralph L ; Sabala, Edison A. ; Rundek, Tatjana ; Juo, Suh Hang Hank ; Huang, Jinaping Sam ; DiTullio, Marco ; Homma, Shunichi ; Almonte, Katihurka ; Lithgow, Carlos García ; Boden-Albala, Bernadette. / Design of a family study among high-risk Caribbean Hispanics : the Northern Manhattan family study. In: Ethnicity and Disease. 2007 ; Vol. 17, No. 2. pp. 351-357.
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