Design and statistical issues in multicenter trials of severe head injury

S. C. Choi; R. Bullock

doi:10.1179/016164101101198325

Design and statistical issues in multicenter trials of severe head injury

S. C. Choi, R. Bullock

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Multicenter clinical trials are the most powerful agent to evaluate new therapies in medicine, but have failed to impact traumatic brain injury, in which at least 20 such trials have been performed, without a positive result. Such trials need to be carefully planned, with a run-in period to ensure center compliance. Stratification, careful monitoring, adequate sample size, interim analysis and adequate numbers of patients per center are all vital requirements for a useful outcome in such trials.

Original language	English (US)
Pages (from-to)	190-192
Number of pages	3
Journal	Neurological Research
Volume	23
Issue number	2-3
DOIs	https://doi.org/10.1179/016164101101198325
State	Published - Apr 23 2001

Keywords

Glasgow Coma Scale
Head injury
Randomised clinical trials
Therapy

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.1179/016164101101198325

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Design and statistical issues in multicenter trials of severe head injury

Abstract

Keywords

ASJC Scopus subject areas

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