Design and statistical issues in multicenter trials of severe head injury

S. C. Choi, R. Bullock

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Multicenter clinical trials are the most powerful agent to evaluate new therapies in medicine, but have failed to impact traumatic brain injury, in which at least 20 such trials have been performed, without a positive result. Such trials need to be carefully planned, with a run-in period to ensure center compliance. Stratification, careful monitoring, adequate sample size, interim analysis and adequate numbers of patients per center are all vital requirements for a useful outcome in such trials.

Original languageEnglish (US)
Pages (from-to)190-192
Number of pages3
JournalNeurological Research
Issue number2-3
StatePublished - Apr 23 2001


  • Glasgow Coma Scale
  • Head injury
  • Randomised clinical trials
  • Therapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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