Design and fabrication of CD-like microfluidic platforms for diagnostic

Mircofluidic functions

M. J. Madou, L. J. Lee, Sylvia Daunert, S. Lai, C. H. Shih

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

In this paper, the design of a polymer based microfluidic compact disk (CD) platform is presented. Several microfluidic functions such as flow sequencing, cascade micro-mixing, and capillary metering can be integrated into the CD by balancing the centrifugal force and the capillary force. These functions are demonstrated experimentally. For flow sequencing, a two-point calibration design is used as an example to show how the release and flow of fluids can be precisely controlled by the rotation speed of the CD. For cascade micro-mixing, a typical application is reconstituting lyophilized protein. A simple metering technique based on bubble snap-off in the two-phase flow is also described.

Original languageEnglish
Pages (from-to)245-254
Number of pages10
JournalBiomedical Microdevices
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Microfluidics
Fabrication
Cascades (fluid mechanics)
Two phase flow
Calibration
Flow of fluids
Polymers
Proteins

Keywords

  • Capillary force
  • CD platform
  • Centrifugal force
  • Flow sequencing
  • Micro-mixing
  • Microfluidic
  • Sample metering

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Neuroscience(all)

Cite this

Design and fabrication of CD-like microfluidic platforms for diagnostic : Mircofluidic functions. / Madou, M. J.; Lee, L. J.; Daunert, Sylvia; Lai, S.; Shih, C. H.

In: Biomedical Microdevices, Vol. 3, No. 3, 01.01.2001, p. 245-254.

Research output: Contribution to journalArticle

Madou, M. J. ; Lee, L. J. ; Daunert, Sylvia ; Lai, S. ; Shih, C. H. / Design and fabrication of CD-like microfluidic platforms for diagnostic : Mircofluidic functions. In: Biomedical Microdevices. 2001 ; Vol. 3, No. 3. pp. 245-254.
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