Design and fabrication of CD-like microfluidic platforms for diagnostic: Mircofluidic functions

Marc J. Madou, L. James Lee, Sylvia Daunert, Siyi Lai, Chih Hsin Shih

Research output: Contribution to journalArticle

196 Scopus citations

Abstract

In this paper, the design of a polymer based microfluidic compact disk (CD) platform is presented. Several microfluidic functions such as flow sequencing, cascade micro-mixing, and capillary metering can be integrated into the CD by balancing the centrifugal force and the capillary force. These functions are demonstrated experimentally. For flow sequencing, a two-point calibration design is used as an example to show how the release and flow of fluids can be precisely controlled by the rotation speed of the CD. For cascade micro-mixing, a typical application is reconstituting lyophilized protein. A simple metering technique based on bubble snap-off in the two-phase flow is also described.

Original languageEnglish (US)
Article number355587
Pages (from-to)245-254
Number of pages10
JournalBiomedical Microdevices
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Capillary force
  • CD platform
  • Centrifugal force
  • Flow sequencing
  • Micro-mixing
  • Microfluidic
  • Sample metering

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Neuroscience(all)

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