Design and analysis in dissemination and implementation research

John Landsverk, C. Hendricks Brown, Justin D. Smith, Patricia Chamberlain, Geoffrey M. Curran, Lawrence Palinkas, Mitsunori Ogihara, Sara Czaja, Jeremy D. Goldhaber-Fiebert, Wouter Vermeer, Lisa Saldana, Jennifer A. Rolls Reutz, Sarah Mccue Horwitz

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations


A wide variety of dissemination and implementation designs are now being used to evaluate and improve health systems and outcomes. This chapter discusses randomized and nonrandomized designs for the traditional translational research continuum or pipeline, which builds on existing efficacy and effectiveness trials to examine how one or more evidence-based clinical/prevention interventions are adopted, scaled up, and sustained in community or service delivery systems. The chapter also considers other designs, including hybrid designs that combine effectiveness and implementation research, and designs that use simulation modeling. A case example of a recent large-scale implementation study is presented as an example of measurement and design considerations in dissemination and implementation research. The chapter provides suggested readings and websites useful for design decisions.

Original languageEnglish (US)
Title of host publicationDissemination and Implementation Research in Health
Subtitle of host publicationTranslating Science to Practice, Second Edition
PublisherOxford University Press
Number of pages28
ISBN (Electronic)9780190683214
StatePublished - Jan 1 2017


  • Designs
  • Hybrid designs
  • Nonrandomized designs
  • Randomized designs
  • Research questions
  • Simulations

ASJC Scopus subject areas

  • Medicine(all)


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