Dermal lymphatic invasion and inflammatory breast cancer are independent predictors of outcome after postmastectomy radiation

Matthew C Abramowitz, Tianyu Li, Monica Morrow, Elin R. Sigurdson, Penny Anderson, Nicos Nicolaou, Gary Freedman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: Inflammatory breast cancer (IBC) is a clinical staging based on history and physical findings. Dermal lymphatic invasion (DLI) can occur with or without IBC. We examine how these independently affect outcome in women treated with postmastectomy radiation. Methods: Four hundred thirty-two patients treated with postmastectomy radiation for invasive mammary cancer were assessed. Kaplan-Meier methodology was used to calculate rates of locoregional recurrence (LRR), distant metastases (DM) and overall survival (OS). Variables entered into univariate and multivariate analysis included T stage, IBC, DLI, estrogen receptor/progesterone receptor status, HER-2/neu status, N stage, extracapsular node extension (ECE), and use of chemotherapy (CT). Median follow-up is 58 months. Results: For all 432 patients, the rate of LRR was 3% and DM 28%. Seven percent are alive with disease (AWD) and 26% are dead of disease (DOD). Thirty-one patients had IBC without DLI, 21 had DLI without IBC, and 18 had both IBC and DLL For DLI 10% developed LRR, 45% DM, 7.5% are AWD and 50% are DOD. Of patients with IBC, 8% developed LRR, 44% DM, 8% are AWD and 48% DOD. DLI was the only significant independent predictor for LRR (HR 4.8, P < 0.05). Predictors of DM and OS were IBC, ≥4 positive nodes, and CT. Conclusions: DLI and IBC are independent predictors of poor outcome after postmastectomy radiation. DLI is associated with an increased risk for LRR, and IBC with worse rates of DM and OS. Patients with both features have worse outcome than those with either alone.

Original languageEnglish
Pages (from-to)30-33
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume32
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

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Inflammatory Breast Neoplasms
Radiation
Skin
Neoplasm Metastasis
Recurrence
Skin Neoplasms
Survival
Drug Therapy
Progesterone Receptors
Estrogen Receptors
Multivariate Analysis
History

Keywords

  • Dermal lymphatic invasion
  • Inflammatory breast cancer
  • Locally advanced breast cancer
  • Postmastectomy radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

Dermal lymphatic invasion and inflammatory breast cancer are independent predictors of outcome after postmastectomy radiation. / Abramowitz, Matthew C; Li, Tianyu; Morrow, Monica; Sigurdson, Elin R.; Anderson, Penny; Nicolaou, Nicos; Freedman, Gary.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 32, No. 1, 01.02.2009, p. 30-33.

Research output: Contribution to journalArticle

Abramowitz, Matthew C ; Li, Tianyu ; Morrow, Monica ; Sigurdson, Elin R. ; Anderson, Penny ; Nicolaou, Nicos ; Freedman, Gary. / Dermal lymphatic invasion and inflammatory breast cancer are independent predictors of outcome after postmastectomy radiation. In: American Journal of Clinical Oncology: Cancer Clinical Trials. 2009 ; Vol. 32, No. 1. pp. 30-33.
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T1 - Dermal lymphatic invasion and inflammatory breast cancer are independent predictors of outcome after postmastectomy radiation

AU - Abramowitz, Matthew C

AU - Li, Tianyu

AU - Morrow, Monica

AU - Sigurdson, Elin R.

AU - Anderson, Penny

AU - Nicolaou, Nicos

AU - Freedman, Gary

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N2 - Objectives: Inflammatory breast cancer (IBC) is a clinical staging based on history and physical findings. Dermal lymphatic invasion (DLI) can occur with or without IBC. We examine how these independently affect outcome in women treated with postmastectomy radiation. Methods: Four hundred thirty-two patients treated with postmastectomy radiation for invasive mammary cancer were assessed. Kaplan-Meier methodology was used to calculate rates of locoregional recurrence (LRR), distant metastases (DM) and overall survival (OS). Variables entered into univariate and multivariate analysis included T stage, IBC, DLI, estrogen receptor/progesterone receptor status, HER-2/neu status, N stage, extracapsular node extension (ECE), and use of chemotherapy (CT). Median follow-up is 58 months. Results: For all 432 patients, the rate of LRR was 3% and DM 28%. Seven percent are alive with disease (AWD) and 26% are dead of disease (DOD). Thirty-one patients had IBC without DLI, 21 had DLI without IBC, and 18 had both IBC and DLL For DLI 10% developed LRR, 45% DM, 7.5% are AWD and 50% are DOD. Of patients with IBC, 8% developed LRR, 44% DM, 8% are AWD and 48% DOD. DLI was the only significant independent predictor for LRR (HR 4.8, P < 0.05). Predictors of DM and OS were IBC, ≥4 positive nodes, and CT. Conclusions: DLI and IBC are independent predictors of poor outcome after postmastectomy radiation. DLI is associated with an increased risk for LRR, and IBC with worse rates of DM and OS. Patients with both features have worse outcome than those with either alone.

AB - Objectives: Inflammatory breast cancer (IBC) is a clinical staging based on history and physical findings. Dermal lymphatic invasion (DLI) can occur with or without IBC. We examine how these independently affect outcome in women treated with postmastectomy radiation. Methods: Four hundred thirty-two patients treated with postmastectomy radiation for invasive mammary cancer were assessed. Kaplan-Meier methodology was used to calculate rates of locoregional recurrence (LRR), distant metastases (DM) and overall survival (OS). Variables entered into univariate and multivariate analysis included T stage, IBC, DLI, estrogen receptor/progesterone receptor status, HER-2/neu status, N stage, extracapsular node extension (ECE), and use of chemotherapy (CT). Median follow-up is 58 months. Results: For all 432 patients, the rate of LRR was 3% and DM 28%. Seven percent are alive with disease (AWD) and 26% are dead of disease (DOD). Thirty-one patients had IBC without DLI, 21 had DLI without IBC, and 18 had both IBC and DLL For DLI 10% developed LRR, 45% DM, 7.5% are AWD and 50% are DOD. Of patients with IBC, 8% developed LRR, 44% DM, 8% are AWD and 48% DOD. DLI was the only significant independent predictor for LRR (HR 4.8, P < 0.05). Predictors of DM and OS were IBC, ≥4 positive nodes, and CT. Conclusions: DLI and IBC are independent predictors of poor outcome after postmastectomy radiation. DLI is associated with an increased risk for LRR, and IBC with worse rates of DM and OS. Patients with both features have worse outcome than those with either alone.

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