@article{b536fb5e7496480a84e167e244ed4149,
title = "Derivation of stem cell line UMi028-A-2 containing a CRISPR/Cas9 induced Alzheimer's disease risk variant p.S1038C in the TTC3 gene",
abstract = "The UMi028-A-2 human induced pluripotent stem cell line carries a homozygous mutation (rs377155188, C>G, p.S1038C) in the tetratricopeptide repeat domain 3 (TTC3) gene that was introduced via CRISPR/Cas9 genome editing. The line was originally derived from a neurologically normal male and has been thoroughly characterized following editing. The p.S1038C variant has been shown to potentially contribute to the risk of late onset Alzheimer's disease and is a resource to further investigate the consequences of TTC3 and this alteration in disease pathology.",
author = "Laverde-Paz, {Mayra Juliana} and Karen Nuytemans and Liyong Wang and Vance, {Jeffery M.} and Pericak-Vance, {Margaret A.} and Dykxhoorn, {Derek M.} and Cukier, {Holly N.}",
note = "Funding Information: This work was funded through the following grant: Ed and Ethel Moore Alzheimer{\textquoteright}s Disease Research Program (Grant # 7AZ20 ) from the Florida Department of Health, Biomedical Research Program , USA, to HNC. Funding Information: This work was funded through the following grant: Ed and Ethel Moore Alzheimer's Disease Research Program (Grant #7AZ20) from the Florida Department of Health, Biomedical Research Program, USA, to HNC. Publisher Copyright: {\textcopyright} 2021 The Author(s)",
year = "2021",
month = apr,
doi = "10.1016/j.scr.2021.102258",
language = "English (US)",
volume = "52",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}