Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer

Angel Alkarain, Joyce Slingerland

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

p27 is a key regulator of progression from G1 to S phase. Although the gene encoding p27 is rarely mutated in human cancers, p27 is functionally inactivated in a majority of human cancers through accelerated p27 proteolysis, through sequestration by cyclin D-cyclin-dependent kinase complexes and by cytoplasmic mislocalization. Here we review mechanisms whereby oncogenic activation of receptor tyrosine kinase and Ras pathways lead to accelerated p27 proteolysis, and p27 mislocalization in cancer cells. The prognostic significance of p27 in human breast cancer is also reviewed.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalBreast Cancer Research
Volume6
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Breast cancer
  • Cell cycle
  • Cyclin-dependent kinase
  • Deregulation
  • p27

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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