Deregulation of cell growth by the K1 gene of Kaposi's sarcoma- associated herpesvirus

Heuiran Lee, Ronald Veazey, Kenneth Williams, Mengtao Li, Jie Guo, Frank Neipel, Bernhard Fleckenstein, Andrew Lackner, Ronald C. Desrosiers, Jae U. Jung

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Abstract

At a position equivalent to the gene encoding the salmiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovlrus subgroup of gamma herpesviruses, K1 and STP exhibit no similarity in amino acid sequence or in structural organization. Since STP is required for the oncogenic potential of HVS, we investigated the functional consequence of K1 expression. Expression of the K1 gene in rodent fibroblasts produced morphologic changes and focus formation indicative of transformation. A recombinant herpesvirus in which the STP oncogene of HVS was replaced with K1, immortalized primary T lymphocytes to IL-2 independent growth and induced lymphoma in common marmosets. These results demonstrate the transforming potential of the K1 gene of KSHV.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalNature medicine
Volume4
Issue number4
DOIs
StatePublished - Apr 1 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lee, H., Veazey, R., Williams, K., Li, M., Guo, J., Neipel, F., Fleckenstein, B., Lackner, A., Desrosiers, R. C., & Jung, J. U. (1998). Deregulation of cell growth by the K1 gene of Kaposi's sarcoma- associated herpesvirus. Nature medicine, 4(4), 435-440. https://doi.org/10.1038/nm0498-435