Depressive symptoms are not influenced by severity of multiple sclerosis

Steven J. Huber, Kottil W. Rammohan, Robert A. Bornstein, Jeffrey A. Christy

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Despite agreement that depression is the most common neuropsychiatric symptom associated with multiple sclerosis (MS), many aspects of this emotional change are unclear. One of the more controversial issues concerns the relationship between severity of MS and depression. This relationship is used to evaluate whether depression is an integral or reactive symptom of MS. Examination of this relationship is complicated by the presumed overlap between somatic features of depressive and neurological symptoms in MS. In order to clarify this situation, we examined the relationship between severity of MS and four categories of depressive symptoms. Results indicated that three of the categories (mood, self-reproach, somatic features) were elevated in patients with MS, but the extent of these elevations were not related to severity of disease. These results suggest that depression in MS is not a simple reaction to physical disability.

Original languageEnglish (US)
Pages (from-to)177-180
Number of pages4
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Issue number3
StatePublished - Jul 1993
Externally publishedYes


  • Mood
  • Self-reproach
  • Somatic symptoms
  • Vegetative symptoms

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Psychology(all)


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