Depressive symptoms and cervical neoplasia in HIV+ low-income minority women with human papillomavirus infection

Stacy M. Dodd, Deidre B. Pereira, Ilona Marion, Michele Andrasik, Rachel Rose, Trudi Simon, Mary Ann Fletcher, Joseph Lucci, Kevin Maher, Mary Jo O'Sullivan, JoNell E Potter, Michael H Antoni

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Prior work has related elevated life stress to greater risk of cervical neoplasia in women with human immunodeficiency virus (HIV) and human papillomavirus (HPV). Purpose: This study investigated associations between depressive symptoms and cervical neoplasia in HIV+ HPV+ women. Participants were 58 HIV+ HPV+ women. Method: Participants underwent colposcopy, including HPV screening, Papanicolaou smear, and cervical biopsy to determine study eligibility. Eligible participants completed the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies-Depression (CES-D) scale. Results: Presence and severity of clinically significant depressive symptomatology were associated with cervical neoplasia. Hierarchical logistic regression analysis revealed that women with greater depressive symptoms had marginally greater odds of presenting with cervical neoplasia (BDI: OR=1.16, p=0.092; CES-D: OR=1.15, p=0.067. Women with greater somatic depressive symptoms, specifically, had significantly greater odds of presenting with cervical neoplasia (BDI: OR=1.86, p=0.027; CES-D: OR=1.56, p=0.017). Conclusion: These findings suggest that screening HIV+ women for somatic depression may help identify those at risk for cervical neoplasia. Future depression research with medical populations should discern somatic depressive symptoms from disease symptoms, as they may have important value in independently predicting health outcomes.

Original languageEnglish
Pages (from-to)181-188
Number of pages8
JournalInternational Journal of Behavioral Medicine
Volume16
Issue number2
DOIs
StatePublished - Jun 1 2009

Fingerprint

Papillomavirus Infections
HIV
Depression
Neoplasms
Epidemiologic Studies
Equipment and Supplies
Papanicolaou Test
Colposcopy
Psychological Stress
Biomedical Research
Logistic Models
Regression Analysis

Keywords

  • Cervical neoplasia
  • Depressive symptoms
  • HIV
  • Human papillomavirus (HPV)
  • Psychoneuroimmunology (PNI)
  • Women

ASJC Scopus subject areas

  • Applied Psychology

Cite this

Depressive symptoms and cervical neoplasia in HIV+ low-income minority women with human papillomavirus infection. / Dodd, Stacy M.; Pereira, Deidre B.; Marion, Ilona; Andrasik, Michele; Rose, Rachel; Simon, Trudi; Fletcher, Mary Ann; Lucci, Joseph; Maher, Kevin; O'Sullivan, Mary Jo; Potter, JoNell E; Antoni, Michael H.

In: International Journal of Behavioral Medicine, Vol. 16, No. 2, 01.06.2009, p. 181-188.

Research output: Contribution to journalArticle

Dodd, SM, Pereira, DB, Marion, I, Andrasik, M, Rose, R, Simon, T, Fletcher, MA, Lucci, J, Maher, K, O'Sullivan, MJ, Potter, JE & Antoni, MH 2009, 'Depressive symptoms and cervical neoplasia in HIV+ low-income minority women with human papillomavirus infection', International Journal of Behavioral Medicine, vol. 16, no. 2, pp. 181-188. https://doi.org/10.1007/s12529-008-9025-1
Dodd, Stacy M. ; Pereira, Deidre B. ; Marion, Ilona ; Andrasik, Michele ; Rose, Rachel ; Simon, Trudi ; Fletcher, Mary Ann ; Lucci, Joseph ; Maher, Kevin ; O'Sullivan, Mary Jo ; Potter, JoNell E ; Antoni, Michael H. / Depressive symptoms and cervical neoplasia in HIV+ low-income minority women with human papillomavirus infection. In: International Journal of Behavioral Medicine. 2009 ; Vol. 16, No. 2. pp. 181-188.
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