Depressive symptoms and carotid intima–media thickness in South American Hispanics: results from the PREVENCION study

Diana A. Chirinos, Josefina Medina-Lezama, Belissa Salinas-Najarro, William Arguelles, Maria Llabre, Neil Schneiderman, Roberto Paz-Manrique, Juan F. Bolanos, Zubair Khan, Julio A. Chirinos

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5 Scopus citations

Abstract

This study aimed to: (1) examine the relationship between depressive symptoms and subclinical atherosclerosis, measured by carotid intima–media thickness (IMT); and, (2) Determine the moderating effect of gender in this relationship among South American Hispanics. We studied 496 adults enrolled in the population-based PREVENCION study. Carotid IMT was measured with high-resolution ultrasonography. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale. Mean carotid IMT was 0.66 mm. (SD = 0.17) and mean depression score was 5.6 (SD = 3.5). Depressive symptoms were not associated with carotid IMT (β = 0.04, p = 0.222) in multivariate analyses. A significant moderating effect of gender was found (β for interaction = 0.10, p = 0.030), resulting from a significant association between depressive symptoms and carotid IMT in men but not women. Depressive symptoms were associated with subclinical atherosclerosis in South American Hispanic men but not women after controlling for demographic characteristics and traditional cardiovascular risk factors.

Original languageEnglish
JournalJournal of Behavioral Medicine
DOIs
StateAccepted/In press - Sep 30 2014

Keywords

  • Cardiovascular disease
  • Carotid intima–media thickness
  • Depression
  • Gender moderation
  • South American Hispanics

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    Chirinos, D. A., Medina-Lezama, J., Salinas-Najarro, B., Arguelles, W., Llabre, M., Schneiderman, N., Paz-Manrique, R., Bolanos, J. F., Khan, Z., & Chirinos, J. A. (Accepted/In press). Depressive symptoms and carotid intima–media thickness in South American Hispanics: results from the PREVENCION study. Journal of Behavioral Medicine. https://doi.org/10.1007/s10865-014-9599-9