Depressive rumination alters cortisol decline in Major Depressive Disorder

Joelle Lemoult, Jutta Joormann

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Depressive rumination - a central characteristic of Major Depressive Disorder (MDD) - is a maladaptive emotion regulation strategy that prolongs sad mood and depressive episodes. Considerable research demonstrates the emotional and behavioral consequences of depressive rumination, yet few studies investigate its effect on neuroendocrine functioning. The current study examined the effect of an emotion regulation manipulation on the trajectory of cortisol concentrations among individuals with MDD and healthy controls (CTL). Sadness was induced via forced failure. Participants then were randomly assigned to a depressive rumination or distraction emotion regulation induction. MDDs in the rumination condition exhibited less cortisol decline compared to MDDs in the distraction condition and compared to CTLs in either condition. Findings suggest that depressive rumination alters the trajectory of cortisol secretion in MDD and may prolong cortisol production. Results thereby provide important insights into the interaction of biological and psychological factors through which distress contributes to MDD.

Original languageEnglish
Pages (from-to)50-55
Number of pages6
JournalBiological Psychology
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Major Depressive Disorder
Hydrocortisone
Emotions
Biological Factors
Psychology
Research

Keywords

  • Cortisol
  • Depression
  • Emotion regulation
  • Experimental
  • HPA axis
  • Rumination

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Depressive rumination alters cortisol decline in Major Depressive Disorder. / Lemoult, Joelle; Joormann, Jutta.

In: Biological Psychology, Vol. 100, No. 1, 01.01.2014, p. 50-55.

Research output: Contribution to journalArticle

Lemoult, Joelle ; Joormann, Jutta. / Depressive rumination alters cortisol decline in Major Depressive Disorder. In: Biological Psychology. 2014 ; Vol. 100, No. 1. pp. 50-55.
@article{fae72f2f4e044e6db8f53e0a2b40b0fa,
title = "Depressive rumination alters cortisol decline in Major Depressive Disorder",
abstract = "Depressive rumination - a central characteristic of Major Depressive Disorder (MDD) - is a maladaptive emotion regulation strategy that prolongs sad mood and depressive episodes. Considerable research demonstrates the emotional and behavioral consequences of depressive rumination, yet few studies investigate its effect on neuroendocrine functioning. The current study examined the effect of an emotion regulation manipulation on the trajectory of cortisol concentrations among individuals with MDD and healthy controls (CTL). Sadness was induced via forced failure. Participants then were randomly assigned to a depressive rumination or distraction emotion regulation induction. MDDs in the rumination condition exhibited less cortisol decline compared to MDDs in the distraction condition and compared to CTLs in either condition. Findings suggest that depressive rumination alters the trajectory of cortisol secretion in MDD and may prolong cortisol production. Results thereby provide important insights into the interaction of biological and psychological factors through which distress contributes to MDD.",
keywords = "Cortisol, Depression, Emotion regulation, Experimental, HPA axis, Rumination",
author = "Joelle Lemoult and Jutta Joormann",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.biopsycho.2014.05.001",
language = "English",
volume = "100",
pages = "50--55",
journal = "Biological Psychology",
issn = "0019-493X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Depressive rumination alters cortisol decline in Major Depressive Disorder

AU - Lemoult, Joelle

AU - Joormann, Jutta

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Depressive rumination - a central characteristic of Major Depressive Disorder (MDD) - is a maladaptive emotion regulation strategy that prolongs sad mood and depressive episodes. Considerable research demonstrates the emotional and behavioral consequences of depressive rumination, yet few studies investigate its effect on neuroendocrine functioning. The current study examined the effect of an emotion regulation manipulation on the trajectory of cortisol concentrations among individuals with MDD and healthy controls (CTL). Sadness was induced via forced failure. Participants then were randomly assigned to a depressive rumination or distraction emotion regulation induction. MDDs in the rumination condition exhibited less cortisol decline compared to MDDs in the distraction condition and compared to CTLs in either condition. Findings suggest that depressive rumination alters the trajectory of cortisol secretion in MDD and may prolong cortisol production. Results thereby provide important insights into the interaction of biological and psychological factors through which distress contributes to MDD.

AB - Depressive rumination - a central characteristic of Major Depressive Disorder (MDD) - is a maladaptive emotion regulation strategy that prolongs sad mood and depressive episodes. Considerable research demonstrates the emotional and behavioral consequences of depressive rumination, yet few studies investigate its effect on neuroendocrine functioning. The current study examined the effect of an emotion regulation manipulation on the trajectory of cortisol concentrations among individuals with MDD and healthy controls (CTL). Sadness was induced via forced failure. Participants then were randomly assigned to a depressive rumination or distraction emotion regulation induction. MDDs in the rumination condition exhibited less cortisol decline compared to MDDs in the distraction condition and compared to CTLs in either condition. Findings suggest that depressive rumination alters the trajectory of cortisol secretion in MDD and may prolong cortisol production. Results thereby provide important insights into the interaction of biological and psychological factors through which distress contributes to MDD.

KW - Cortisol

KW - Depression

KW - Emotion regulation

KW - Experimental

KW - HPA axis

KW - Rumination

UR - http://www.scopus.com/inward/record.url?scp=84902010381&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902010381&partnerID=8YFLogxK

U2 - 10.1016/j.biopsycho.2014.05.001

DO - 10.1016/j.biopsycho.2014.05.001

M3 - Article

C2 - 24835412

AN - SCOPUS:84902010381

VL - 100

SP - 50

EP - 55

JO - Biological Psychology

JF - Biological Psychology

SN - 0019-493X

IS - 1

ER -