Depressive Disorders in Epilepsy

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Depressive disorders are the most frequent psychiatric comorbidity in epilepsy, occurring in one out of every three to four patients in the course of their life. Unfortunately, depressive disorders remain underrecognized and undertreated. The presence of a depressive disorder can impact the life of patients with epilepsy (PWE) at several levels because they can significantly worsen quality of life, increase suicidal risk, and worsen the response of seizure disorders to pharmacological and surgical treatment. Depressive disorders in PWE may mimic primary depressive disorders; however, in a significant percentage of patients they present with atypical clinical manifestations as a pleomorphic disorder associated with frequent symptoms of anxiety, irritability, and pain. Depressive disorders have a bidirectional relationship with epilepsy, which is explained by the existence of common pathogenic mechanisms operant in both conditions. This bidirectional relationship explains the relatively high comorbidity of depressive disorders in PWE and may provide answers regarding the worse prognosis of the seizure disorder in depressed patients. The use of screening self-rating scales may help to identify depressive episodes in PWE, but a diagnosis cannot be established without an additional, in-depth evaluation. Given the negative impact of depression in PWE, its timely recognition and treatment is of the essence in epilepsy patients.

Original languageEnglish (US)
Title of host publicationDepression in Neurologic Disorders
Subtitle of host publicationDiagnosis and Management
Number of pages19
ISBN (Print)9781444330588
StatePublished - Jul 4 2012
Externally publishedYes


  • Anxiety disorder
  • Bidirectional relation
  • Interictal dysphoric disorder
  • Major depressive disorders

ASJC Scopus subject areas

  • Neuroscience(all)


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