Depression of cytidine 3'

5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs

D. M. Helfman, Nancy Brackett, J. F. Kuo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Changes in levels of the newly discovered cytidine 3':5'-cyclic monophosphate (cyclic CMP) phosphodiesterase in some representative tissues (cerebral cortex, kidney, intestine, liver, heart, and lung) of guinea pigs from various developmental stages (fetus, neonate, pup, and adult) were studied and compared with those of cyclic AMP and cyclic GMP phosphodiesterases in the same tissues. It was observed that the tissue levels of cyclic CMP phosphodiesterase were invariably the lowest in every one of the fetal tissues examined, the highest in the corresponding tissues from the pups and adult, with intermediate levels seen in some neonatal tissues. The patterns of the ontogenetic changes in levels of cyclic AMP and cyclic GMP phosphodiesterase activities, however, were variable and tissue specific. These findings suggest that the depressed cyclic CMP phosphodiesterase activity (hence, the elevated cyclic/CMP concentration) is perhaps a common factor in developing tissues undergoing rapid cell proliferation. The data also suggest that metabolism of cyclic CMP is perhaps more closely related to cell proliferation than the metabolism of cyclic AMP or cyclic GMP.

Original languageEnglish
Pages (from-to)4422-4425
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number9
StatePublished - Dec 1 1978
Externally publishedYes

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Cytidine
Phosphoric Diester Hydrolases
Guinea Pigs
2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
Cyclic CMP
Cyclic GMP
Cyclic AMP
Fetus
Cell Proliferation
Cerebral Cortex
Intestines
Kidney
Lung
Liver

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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abstract = "Changes in levels of the newly discovered cytidine 3':5'-cyclic monophosphate (cyclic CMP) phosphodiesterase in some representative tissues (cerebral cortex, kidney, intestine, liver, heart, and lung) of guinea pigs from various developmental stages (fetus, neonate, pup, and adult) were studied and compared with those of cyclic AMP and cyclic GMP phosphodiesterases in the same tissues. It was observed that the tissue levels of cyclic CMP phosphodiesterase were invariably the lowest in every one of the fetal tissues examined, the highest in the corresponding tissues from the pups and adult, with intermediate levels seen in some neonatal tissues. The patterns of the ontogenetic changes in levels of cyclic AMP and cyclic GMP phosphodiesterase activities, however, were variable and tissue specific. These findings suggest that the depressed cyclic CMP phosphodiesterase activity (hence, the elevated cyclic/CMP concentration) is perhaps a common factor in developing tissues undergoing rapid cell proliferation. The data also suggest that metabolism of cyclic CMP is perhaps more closely related to cell proliferation than the metabolism of cyclic AMP or cyclic GMP.",
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T2 - 5'-cyclic monophosphate phosphodiesterase activity in developing tissues of guinea pigs

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AU - Kuo, J. F.

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