Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes

Veronica Cardenas, Brent T. Mausbach, David Sommerfeld, Daniel Enrique Jimenez, Roland von Känel, Jennifer S. Ho, Piedad Garcia, Gregory A. Aarons

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Latino adults are 66% more likely to have diabetes relative to non-Latino white adults. Prior research identifies depression as a significant risk factor for metabolic syndrome (MetS), but research examining this among Latinos is lacking. This study sought to examine the links between depression and MetS and clinically significant elevations in cardiovascular disease risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. Methods: Participants were 332 community-dwelling older (≥60 years) Latinos with type 2 diabetes who completed the nine-item Patient Health Questionnaire and received a health checkup assessing body mass index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression with those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (e.g., income, age) and other potential MetS risk factors (e.g., smoking status, physical activity, alcohol level consumption). Results: Depression was significantly associated with an increased risk of MetS (OR: 5.79; 95% CI: 1.32-25.42) and clinically significant elevations in triglycerides (OR: 2.71; 95% CI: 1.15-6.42) and reduced (HDL) cholesterol (OR: 2.46; 95% CI: 1.11-5.45). A significant association was not observed between depression and either BMI or hypertension. Conclusion: Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. Causation, however, cannot be inferred from these analyses given the cross-sectional nature of the study. Future research should prospectively examine the directionality of this effect.

Original languageEnglish (US)
JournalAmerican Journal of Geriatric Psychiatry
DOIs
StateAccepted/In press - Oct 19 2016

Fingerprint

Hispanic Americans
Type 2 Diabetes Mellitus
Depression
Independent Living
HDL Cholesterol
Triglycerides
Body Mass Index
Health
Dyslipidemias
Research
Alcohol Drinking
Causality
Cardiovascular Diseases
Cross-Sectional Studies
Logistic Models
Smoking
Regression Analysis
Demography
Exercise
Blood Pressure

Keywords

  • Cardiovascular disease risk
  • Depression
  • Diabetes
  • Latino
  • Metabolic syndrome

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes. / Cardenas, Veronica; Mausbach, Brent T.; Sommerfeld, David; Jimenez, Daniel Enrique; von Känel, Roland; Ho, Jennifer S.; Garcia, Piedad; Aarons, Gregory A.

In: American Journal of Geriatric Psychiatry, 19.10.2016.

Research output: Contribution to journalArticle

Cardenas, Veronica ; Mausbach, Brent T. ; Sommerfeld, David ; Jimenez, Daniel Enrique ; von Känel, Roland ; Ho, Jennifer S. ; Garcia, Piedad ; Aarons, Gregory A. / Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes. In: American Journal of Geriatric Psychiatry. 2016.
@article{b2c93738728e46969507ac5b7877bac1,
title = "Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes",
abstract = "Objective: Latino adults are 66{\%} more likely to have diabetes relative to non-Latino white adults. Prior research identifies depression as a significant risk factor for metabolic syndrome (MetS), but research examining this among Latinos is lacking. This study sought to examine the links between depression and MetS and clinically significant elevations in cardiovascular disease risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. Methods: Participants were 332 community-dwelling older (≥60 years) Latinos with type 2 diabetes who completed the nine-item Patient Health Questionnaire and received a health checkup assessing body mass index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression with those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (e.g., income, age) and other potential MetS risk factors (e.g., smoking status, physical activity, alcohol level consumption). Results: Depression was significantly associated with an increased risk of MetS (OR: 5.79; 95{\%} CI: 1.32-25.42) and clinically significant elevations in triglycerides (OR: 2.71; 95{\%} CI: 1.15-6.42) and reduced (HDL) cholesterol (OR: 2.46; 95{\%} CI: 1.11-5.45). A significant association was not observed between depression and either BMI or hypertension. Conclusion: Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. Causation, however, cannot be inferred from these analyses given the cross-sectional nature of the study. Future research should prospectively examine the directionality of this effect.",
keywords = "Cardiovascular disease risk, Depression, Diabetes, Latino, Metabolic syndrome",
author = "Veronica Cardenas and Mausbach, {Brent T.} and David Sommerfeld and Jimenez, {Daniel Enrique} and {von K{\"a}nel}, Roland and Ho, {Jennifer S.} and Piedad Garcia and Aarons, {Gregory A.}",
year = "2016",
month = "10",
day = "19",
doi = "10.1016/j.jagp.2017.02.017",
language = "English (US)",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes

AU - Cardenas, Veronica

AU - Mausbach, Brent T.

AU - Sommerfeld, David

AU - Jimenez, Daniel Enrique

AU - von Känel, Roland

AU - Ho, Jennifer S.

AU - Garcia, Piedad

AU - Aarons, Gregory A.

PY - 2016/10/19

Y1 - 2016/10/19

N2 - Objective: Latino adults are 66% more likely to have diabetes relative to non-Latino white adults. Prior research identifies depression as a significant risk factor for metabolic syndrome (MetS), but research examining this among Latinos is lacking. This study sought to examine the links between depression and MetS and clinically significant elevations in cardiovascular disease risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. Methods: Participants were 332 community-dwelling older (≥60 years) Latinos with type 2 diabetes who completed the nine-item Patient Health Questionnaire and received a health checkup assessing body mass index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression with those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (e.g., income, age) and other potential MetS risk factors (e.g., smoking status, physical activity, alcohol level consumption). Results: Depression was significantly associated with an increased risk of MetS (OR: 5.79; 95% CI: 1.32-25.42) and clinically significant elevations in triglycerides (OR: 2.71; 95% CI: 1.15-6.42) and reduced (HDL) cholesterol (OR: 2.46; 95% CI: 1.11-5.45). A significant association was not observed between depression and either BMI or hypertension. Conclusion: Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. Causation, however, cannot be inferred from these analyses given the cross-sectional nature of the study. Future research should prospectively examine the directionality of this effect.

AB - Objective: Latino adults are 66% more likely to have diabetes relative to non-Latino white adults. Prior research identifies depression as a significant risk factor for metabolic syndrome (MetS), but research examining this among Latinos is lacking. This study sought to examine the links between depression and MetS and clinically significant elevations in cardiovascular disease risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. Methods: Participants were 332 community-dwelling older (≥60 years) Latinos with type 2 diabetes who completed the nine-item Patient Health Questionnaire and received a health checkup assessing body mass index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression with those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (e.g., income, age) and other potential MetS risk factors (e.g., smoking status, physical activity, alcohol level consumption). Results: Depression was significantly associated with an increased risk of MetS (OR: 5.79; 95% CI: 1.32-25.42) and clinically significant elevations in triglycerides (OR: 2.71; 95% CI: 1.15-6.42) and reduced (HDL) cholesterol (OR: 2.46; 95% CI: 1.11-5.45). A significant association was not observed between depression and either BMI or hypertension. Conclusion: Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. Causation, however, cannot be inferred from these analyses given the cross-sectional nature of the study. Future research should prospectively examine the directionality of this effect.

KW - Cardiovascular disease risk

KW - Depression

KW - Diabetes

KW - Latino

KW - Metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=85015716686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015716686&partnerID=8YFLogxK

U2 - 10.1016/j.jagp.2017.02.017

DO - 10.1016/j.jagp.2017.02.017

M3 - Article

C2 - 28341138

AN - SCOPUS:85015716686

JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

ER -