Depression, immunocompetence, and prostaglandins of the E series

Joseph R. Calabrese, Robert G. Skwerer, Barbara Barna, A. Dale Gulledge, Rafael Valenzuela, Antanas Butkus, Steven Subichin, Neal E. Krupp

Research output: Contribution to journalArticlepeer-review

178 Scopus citations


Plasma prostaglandin E1 and E2, and quantitative and qualitative measures of immune function, were determined in depressed patients and healthy controls. Prostaglandin E2 was significantly elevated in the depressed group, and prostaglandin E1 showed a trend in the same direction. Lymphocyte stimulation responses, as measured by phytohemagglutinin, concanavalin A, and pokeweed mitogen, were significantly lower in the depressed group. Helper and suppressor T cell percentages did not significantly differ in the two populations. In the depressed group, prostaglandin E1 showed a significant inverse correlation with concanavalin A, and prostaglandin E2 showed a similar trend. These preliminary data suggest prostaglandins of the E series may be related to abnormalities of cellular immunity previously documented in depression.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalPsychiatry Research
Issue number1
StatePublished - Jan 1986


  • Depression
  • T cell subsets
  • immunomodulation
  • lymphocyte transformation testing
  • prostaglandin E and E

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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